Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EFL38184.1Hydroxymethylglutaryl-coenzyme A reductase. (354 aa)    
Predicted Functional Partners:
EFL38183.1
hydroxymethylglutaryl-CoA synthase.
 
 
 0.997
EFL38188.1
Mevalonate kinase.
 
 0.988
EFL38186.1
Phosphomevalonate kinase.
 
 0.981
EFL38187.1
Diphosphomevalonate decarboxylase.
 
 
 0.978
EFL43496.1
Polyketide TA biosynthesis protein TaC.
 
 
 0.974
fni
Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
   
 0.958
EFL38189.1
Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
  
 
 0.839
EFL39369.1
PE-PGRS family protein.
    
 
 0.771
EFL38182.1
Conserved hypothetical protein.
       0.670
EFL38135.1
Polyprenyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.
 
 
 0.659
Your Current Organism:
Streptomyces griseoflavus
NCBI taxonomy Id: 467200
Other names: S. griseoflavus Tu4000, Streptomyces griseoflavus Tu4000, Streptomyces griseoflavus str. Tu4000, Streptomyces griseoflavus strain Tu4000
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.