Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
co-expression
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gene neighborhood
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[Homology]
Score
tdkThymidine kinase. (216 aa)    
Predicted Functional Partners:
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.970
EFL37290.1
Thymidylate synthase.
  
 
 0.964
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.964
EFL39528.1
Cytidine deaminase.
 
  
 0.949
EFL40040.1
dTMP kinase.
  
 
 0.945
EFL39527.1
Thymidine phosphorylase.
 
  
 0.927
EFL40605.1
5`-nucleotidase; Belongs to the 5'-nucleotidase family.
    
  0.860
EFL41186.1
Sugar phosphatase/hydrolase; Belongs to the HAD-like hydrolase superfamily.
     
  0.850
EFL41904.1
2',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family.
 
  
  0.831
EFL38673.1
Phosphodiesterase; Unextendable partial coding region.
    
  0.804
Your Current Organism:
Streptomyces griseoflavus
NCBI taxonomy Id: 467200
Other names: S. griseoflavus Tu4000, Streptomyces griseoflavus Tu4000, Streptomyces griseoflavus str. Tu4000, Streptomyces griseoflavus strain Tu4000
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