Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EFL38697.1DNA hydrolase with MutT domain-containing protein; Belongs to the Nudix hydrolase family. (283 aa)    
Predicted Functional Partners:
EFL39989.1
L-aspartate oxidase (LASPO) (Quinolinate synthetase B).
  
 
 0.879
nadE
phenylalanyl-tRNA synthetase, beta subunit; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.786
nadA
Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
  
  
 0.750
EFL39988.1
Nicotinate-nucleotide diphosphorylase; Belongs to the NadC/ModD family.
  
 
 0.724
EFL42248.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.704
EFL39367.1
Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
  0.620
ribBA
3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
    
  0.613
EFL42695.1
Hypothetical protein.
    
 0.577
sigA
RNA polymerase sigma (70) factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
       0.552
EFL38695.1
Sporulation transcription factor, WhiH.
       0.552
Your Current Organism:
Streptomyces griseoflavus
NCBI taxonomy Id: 467200
Other names: S. griseoflavus Tu4000, Streptomyces griseoflavus Tu4000, Streptomyces griseoflavus str. Tu4000, Streptomyces griseoflavus strain Tu4000
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.