Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EFL38842.1SMF protein. (386 aa)    
Predicted Functional Partners:
EFL39829.1
Type IV peptidase; Belongs to the peptidase A24 family.
  
  
 0.852
EFL41047.1
Conserved hypothetical protein.
 
 
 0.802
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.764
EFL38843.1
Conserved hypothetical protein; Belongs to the UPF0102 family.
 
  
 0.759
topA
DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...]
 
   
 0.730
EFL38841.1
RNA polymerase sigma factor WhiG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
       0.720
EFL37442.1
PAS/PAC sensor hybrid histidine kinase.
  
  
 0.700
EFL37443.1
PAS/PAC sensor hybrid histidine kinase.
  
  
 0.700
EFL38929.1
Sensory box/GGDEF domain/EAL domain-containing protein.
   
    0.689
EFL38840.1
Transcriptional regulator.
       0.670
Your Current Organism:
Streptomyces griseoflavus
NCBI taxonomy Id: 467200
Other names: S. griseoflavus Tu4000, Streptomyces griseoflavus Tu4000, Streptomyces griseoflavus str. Tu4000, Streptomyces griseoflavus strain Tu4000
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