STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EFL38930.1Dehydrogenase. (317 aa)    
Predicted Functional Partners:
serC
Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
  
 0.810
EFL38927.1
Acetolactate synthase, small subunit.
  
 
 0.740
EFL39170.1
Oxoglutarate dehydrogenase (succinyl-transferring), E1 component.
     
 0.710
EFL38925.1
Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
  
 
0.702
EFL38537.1
Ferredoxin oxidoreductase, alpha subunit.
  
 
 0.689
EFL39776.1
Ferredoxin oxidoreductase, alpha subunit.
  
 
 0.689
EFL42472.1
Lysine monooxygenase.
    
 0.684
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.683
EFL41886.1
Tryptophan synthase subunit alpha; Belongs to the TrpA family.
   
 
 0.668
EFL38928.1
Acetolactate synthase, large subunit, biosynthetic type.
  
 
 0.661
Your Current Organism:
Streptomyces griseoflavus
NCBI taxonomy Id: 467200
Other names: S. griseoflavus Tu4000, Streptomyces griseoflavus Tu4000, Streptomyces griseoflavus str. Tu4000, Streptomyces griseoflavus strain Tu4000
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.