| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFL38972.1 | EFL41895.1 | SSRG_01776 | SSRG_04699 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glutamate synthase large subunit. | 0.602 |
| EFL38972.1 | EFL42114.1 | SSRG_01776 | SSRG_04918 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Phosphoserine phosphatase. | 0.905 |
| EFL38972.1 | gcvH | SSRG_01776 | SSRG_01774 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.805 |
| EFL38972.1 | gcvT | SSRG_01776 | SSRG_01773 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.886 |
| EFL38972.1 | glyA-2 | SSRG_01776 | SSRG_01892 | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.882 |
| EFL41895.1 | EFL38972.1 | SSRG_04699 | SSRG_01776 | Glutamate synthase large subunit. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.602 |
| EFL41895.1 | EFL42248.1 | SSRG_04699 | SSRG_05052 | Glutamate synthase large subunit. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.546 |
| EFL41895.1 | EFL43484.1 | SSRG_04699 | SSRG_06288 | Glutamate synthase large subunit. | Polyketide synthase. | 0.948 |
| EFL41895.1 | folD | SSRG_04699 | SSRG_02395 | Glutamate synthase large subunit. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.638 |
| EFL41895.1 | gcvH | SSRG_04699 | SSRG_01774 | Glutamate synthase large subunit. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.938 |
| EFL41895.1 | gcvT | SSRG_04699 | SSRG_01773 | Glutamate synthase large subunit. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.927 |
| EFL41895.1 | glyA-2 | SSRG_04699 | SSRG_01892 | Glutamate synthase large subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.909 |
| EFL41895.1 | purH | SSRG_04699 | SSRG_02398 | Glutamate synthase large subunit. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.946 |
| EFL41895.1 | purN | SSRG_04699 | SSRG_02399 | Glutamate synthase large subunit. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.416 |
| EFL42114.1 | EFL38972.1 | SSRG_04918 | SSRG_01776 | Phosphoserine phosphatase. | L-serine ammonia-lyase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.905 |
| EFL42114.1 | EFL42248.1 | SSRG_04918 | SSRG_05052 | Phosphoserine phosphatase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.866 |
| EFL42114.1 | EFL43484.1 | SSRG_04918 | SSRG_06288 | Phosphoserine phosphatase. | Polyketide synthase. | 0.449 |
| EFL42114.1 | glyA-2 | SSRG_04918 | SSRG_01892 | Phosphoserine phosphatase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
| EFL42248.1 | EFL41895.1 | SSRG_05052 | SSRG_04699 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase large subunit. | 0.546 |
| EFL42248.1 | EFL42114.1 | SSRG_05052 | SSRG_04918 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoserine phosphatase. | 0.866 |
