Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
EFL39262.1Thiazole biosynthesis adenylyltransferase ThiF. (392 aa)    
Predicted Functional Partners:
EFL39237.1
Molybdopterin converting factor, subunit 2.
 
 0.991
thiG
Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.991
EFL40697.1
ThiS family protein.
 
 0.986
EFL41142.1
MoaD family protein.
 
 0.986
EFL41808.1
Thiamine biosynthesis protein ThiS.
  
 0.986
EFL38957.1
Aminotransferase, class V.
 
 
 0.968
EFL41765.1
Cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent; Belongs to the sulfur carrier protein TusA family.
   
 0.963
EFL40614.1
Molybdopterin converting factor.
  
 0.961
EFL41141.1
Mov34/MPN/PAD-1 family protein.
 
 0.945
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 
 0.909
Your Current Organism:
Streptomyces griseoflavus
NCBI taxonomy Id: 467200
Other names: S. griseoflavus Tu4000, Streptomyces griseoflavus Tu4000, Streptomyces griseoflavus str. Tu4000, Streptomyces griseoflavus strain Tu4000
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