Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (321 aa)    
Predicted Functional Partners:
lipB
Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.999
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.958
EFL38067.1
Lipoate-protein ligase.
  
 
 0.900
EFL37526.1
Conserved hypothetical protein; Truncated CDS; unextendable partial coding region.
  
 0.899
EFL40320.1
Pyruvate dehydrogenase E2.
 
 
 0.804
EFL41745.1
2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase.
 
 
 0.791
EFL40307.1
Pyruvate dehydrogenase E2.
 
 
 0.781
EFL39170.1
Oxoglutarate dehydrogenase (succinyl-transferring), E1 component.
 
 
 0.770
EFL41733.1
Conserved hypothetical protein.
       0.722
EFL41732.1
Integral membrane protein.
       0.681
Your Current Organism:
Streptomyces griseoflavus
NCBI taxonomy Id: 467200
Other names: S. griseoflavus Tu4000, Streptomyces griseoflavus Tu4000, Streptomyces griseoflavus str. Tu4000, Streptomyces griseoflavus strain Tu4000
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