STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purDKEGG: bpb:bpr_I0870 7.1e-167 purD; phosphoribosylamine-glycine ligase PurD K01945; Psort location: Cytoplasmic, score: 9.97; Belongs to the GARS family. (424 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 0.999
purM
KEGG: csh:Closa_1608 1.8e-138 phosphoribosylformylglycinamidine cyclo-ligase K01933; Psort location: Cytoplasmic, score: 9.97.
 
 0.999
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
 0.999
KXB59985.1
KEGG: csh:Closa_1348 0. phosphoribosylformylglycinamidine synthase K01952; Psort location: Cytoplasmic, score: 9.94.
 
 0.999
KXB56353.1
KEGG: cle:Clole_1571 2.0e-185 amidophosphoribosyltransferase K00764; Psort location: Cytoplasmic, score: 8.96; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 0.998
KXB56828.1
AICARFT/IMPCHase bienzyme; KEGG: rho:RHOM_09910 6.5e-157 5-aminoimidazole-4-carboxamide ribonucleotide transformylase K00602; Psort location: Cytoplasmic, score: 9.97.
 
 0.991
purC
KEGG: csh:Closa_1577 4.6e-101 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923; Psort location: Cytoplasmic, score: 9.97; Belongs to the SAICAR synthetase family.
 
 0.990
KXB54890.1
Adenylosuccinate lyase; KEGG: csh:Closa_1579 5.3e-194 adenylosuccinate lyase; K01756 adenylosuccinate lyase; Psort location: Cytoplasmic, score: 9.97.
  
 0.980
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 
 0.969
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.927
Your Current Organism:
Lachnoanaerobaculum saburreum
NCBI taxonomy Id: 467210
Other names: ATCC 33271, CCUG 28089, CIP 105341, Catenabacterium saburreum, DSM 3986, Eubacterium saburreum, JCM 11021, L. saburreum, Leptotrichia aerogenes, VPI 11763
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