STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (405 aa)    
Predicted Functional Partners:
pgi
KEGG: csh:Closa_0057 5.6e-190 glucose-6-phosphate isomerase K01810; Psort location: Cytoplasmic, score: 9.97; Belongs to the GPI family.
  
 0.990
fbp
KEGG: ere:EUBREC_0921 2.9e-264 fructose-1,6-bisphosphatase; K04041 fructose-1,6-bisphosphatase III; Psort location: Cytoplasmic, score: 8.96.
     
 0.944
pfkA-2
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
  
  
0.922
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  
  
0.914
KXB60660.1
1-phosphofructokinase; KEGG: aur:HMPREF9243_1310 3.0e-72 pfkB; 1-phosphofructokinase K00882; Psort location: Cytoplasmic, score: 9.97; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
     
 0.898
KXB56352.1
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 
 0.898
KXB53527.1
KEGG: rho:RHOM_02510 2.1e-128 fructose-1,6-bisphosphate aldolase, class II; K01624 fructose-bisphosphate aldolase, class II; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.897
tal
Fructose-6-phosphate aldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
  
 
 0.896
dxs
1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
    
 0.865
KXB59533.1
Ketose-bisphosphate aldolase; KEGG: mas:Mahau_0254 2.2e-46 fructose-bisphosphate aldolase K01624; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.856
Your Current Organism:
Lachnoanaerobaculum saburreum
NCBI taxonomy Id: 467210
Other names: ATCC 33271, CCUG 28089, CIP 105341, Catenabacterium saburreum, DSM 3986, Eubacterium saburreum, JCM 11021, L. saburreum, Leptotrichia aerogenes, VPI 11763
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