| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXB54018.1 | rsmG | HMPREF1866_02414 | HMPREF1866_02417 | Putative stage 0 sporulation protein J; KEGG: pub:SAR11_0354 5.8e-46 parB; chromosome partitioning protein K03497; Psort location: Cytoplasmic, score: 9.94; Belongs to the ParB family. | 16S rRNA methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. | 0.708 |
| KXB54024.1 | KXB54025.1 | HMPREF1866_02420 | HMPREF1866_02421 | r3H domain protein; KEGG: sgg:SGGBAA2069_c20720 1.8e-12 jag; Jag family RNA-binding protein K06346. | Membrane protein insertase, YidC/Oxa1 family; Psort location: CytoplasmicMembrane, score: 10.00. | 0.955 |
| KXB54024.1 | mnmE | HMPREF1866_02420 | HMPREF1866_02419 | r3H domain protein; KEGG: sgg:SGGBAA2069_c20720 1.8e-12 jag; Jag family RNA-binding protein K06346. | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.742 |
| KXB54024.1 | mnmG | HMPREF1866_02420 | HMPREF1866_02418 | r3H domain protein; KEGG: sgg:SGGBAA2069_c20720 1.8e-12 jag; Jag family RNA-binding protein K06346. | tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. | 0.705 |
| KXB54024.1 | rnpA | HMPREF1866_02420 | HMPREF1866_02423 | r3H domain protein; KEGG: sgg:SGGBAA2069_c20720 1.8e-12 jag; Jag family RNA-binding protein K06346. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.918 |
| KXB54024.1 | rsmG | HMPREF1866_02420 | HMPREF1866_02417 | r3H domain protein; KEGG: sgg:SGGBAA2069_c20720 1.8e-12 jag; Jag family RNA-binding protein K06346. | 16S rRNA methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. | 0.863 |
| KXB54025.1 | KXB54024.1 | HMPREF1866_02421 | HMPREF1866_02420 | Membrane protein insertase, YidC/Oxa1 family; Psort location: CytoplasmicMembrane, score: 10.00. | r3H domain protein; KEGG: sgg:SGGBAA2069_c20720 1.8e-12 jag; Jag family RNA-binding protein K06346. | 0.955 |
| KXB54025.1 | guaB | HMPREF1866_02421 | HMPREF1866_00141 | Membrane protein insertase, YidC/Oxa1 family; Psort location: CytoplasmicMembrane, score: 10.00. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.462 |
| KXB54025.1 | mnmE | HMPREF1866_02421 | HMPREF1866_02419 | Membrane protein insertase, YidC/Oxa1 family; Psort location: CytoplasmicMembrane, score: 10.00. | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.782 |
| KXB54025.1 | mnmG | HMPREF1866_02421 | HMPREF1866_02418 | Membrane protein insertase, YidC/Oxa1 family; Psort location: CytoplasmicMembrane, score: 10.00. | tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. | 0.843 |
| KXB54025.1 | rnpA | HMPREF1866_02421 | HMPREF1866_02423 | Membrane protein insertase, YidC/Oxa1 family; Psort location: CytoplasmicMembrane, score: 10.00. | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. | 0.970 |
| KXB54025.1 | rsmG | HMPREF1866_02421 | HMPREF1866_02417 | Membrane protein insertase, YidC/Oxa1 family; Psort location: CytoplasmicMembrane, score: 10.00. | 16S rRNA methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. | 0.833 |
| KXB54502.1 | rsmG | HMPREF1866_02354 | HMPREF1866_02417 | MT-A70 protein; KEGG: dku:Desku_1126 3.1e-22 adenine-specific DNA methyltransferase; Psort location: Cytoplasmic, score: 8.96; Belongs to the MT-A70-like family. | 16S rRNA methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. | 0.670 |
| der | guaB | HMPREF1866_01422 | HMPREF1866_00141 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.533 |
| der | rsmG | HMPREF1866_01422 | HMPREF1866_02417 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 16S rRNA methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. | 0.568 |
| guaB | KXB54025.1 | HMPREF1866_00141 | HMPREF1866_02421 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Membrane protein insertase, YidC/Oxa1 family; Psort location: CytoplasmicMembrane, score: 10.00. | 0.462 |
| guaB | der | HMPREF1866_00141 | HMPREF1866_01422 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.533 |
| guaB | mnmG | HMPREF1866_00141 | HMPREF1866_02418 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. | 0.578 |
| guaB | rsmG | HMPREF1866_00141 | HMPREF1866_02417 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 16S rRNA methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. | 0.640 |
| mnmE | KXB54024.1 | HMPREF1866_02419 | HMPREF1866_02420 | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | r3H domain protein; KEGG: sgg:SGGBAA2069_c20720 1.8e-12 jag; Jag family RNA-binding protein K06346. | 0.742 |