STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (483 aa)    
Predicted Functional Partners:
KXB53961.1
KEGG: ere:EUBREC_2979 1.9e-72 anthranilate/para-aminobenzoate synthase component II, TrpG; K01658 anthranilate synthase component II; Psort location: Cytoplasmic, score: 9.97.
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 0.999
trpC
KEGG: bpb:bpr_I0011 1.1e-85 trpC; indole-3-glycerol phosphate synthase K01609; Psort location: Cytoplasmic, score: 9.97; Belongs to the TrpC family.
 0.999
trpF
KEGG: bpb:bpr_I0010 7.4e-46 trpF; phosphoribosylanthranilate isomerase TrpF K01817; Psort location: Cytoplasmic, score: 8.96; Belongs to the TrpF family.
 
 
 0.997
trpB-2
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.994
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.991
KXB53574.1
Prephenate dehydratase; KEGG: bpb:bpr_I1730 1.8e-74 pheA; chorismate mutase K14170; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.957
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.940
KXB60757.1
Chorismate mutase; KEGG: cno:NT01CX_0622 2.3e-19 chorismate mutase; K04093 chorismate mutase.
  
 
 0.913
KXB53959.1
3-deoxy-7-phosphoheptulonate synthase; KEGG: cls:CXIVA_12380 6.6e-109 hypothetical protein; K03856 3-deoxy-7-phosphoheptulonate synthase; Psort location: Cytoplasmic, score: 9.97.
    
 0.912
Your Current Organism:
Lachnoanaerobaculum saburreum
NCBI taxonomy Id: 467210
Other names: ATCC 33271, CCUG 28089, CIP 105341, Catenabacterium saburreum, DSM 3986, Eubacterium saburreum, JCM 11021, L. saburreum, Leptotrichia aerogenes, VPI 11763
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