pdam_00005042 protein (Pocillopora damicornis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

pdam_00005042

Uncharacterized protein. (355 aa)

Predicted Functional Partners:

pdam_00000901

0.991

pdam_00010697

0.991

pdam_00008942

0.991

pdam_00008166

0.991

pdam_00017524

0.991

pdam_00017523

0.991

pdam_00002301

0.991

pdam_00021236

0.991

pdam_00002098

0.991

pdam_00018324

0.991

Your Current Organism:

Pocillopora damicornis

NCBI taxonomy Id: 46731
Other names: P. damicornis, Pocillopora caespitosa laysanensis, Pocillopora damicornis laysanensis, cauliflower coral, lace coral

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
pdam_00000901	pdam_00005042	A0A3M6T6A1	A0A3M6T6M9	Uncharacterized protein.	Uncharacterized protein.	0.991
pdam_00000901	pdam_00017524	A0A3M6T6A1	A0A3M6TCF1	Uncharacterized protein.	SUEL-type lectin domain-containing protein.	0.440
pdam_00002098	pdam_00005042	A0A3M6U1F9	A0A3M6T6M9	Uncharacterized protein.	Uncharacterized protein.	0.991
pdam_00002301	pdam_00005042	A0A3M6TFB2	A0A3M6T6M9	G_PROTEIN_RECEP_F2_4 domain-containing protein.	Uncharacterized protein.	0.991
pdam_00005042	pdam_00000901	A0A3M6T6M9	A0A3M6T6A1	Uncharacterized protein.	Uncharacterized protein.	0.991
pdam_00005042	pdam_00002098	A0A3M6T6M9	A0A3M6U1F9	Uncharacterized protein.	Uncharacterized protein.	0.991
pdam_00005042	pdam_00002301	A0A3M6T6M9	A0A3M6TFB2	Uncharacterized protein.	G_PROTEIN_RECEP_F2_4 domain-containing protein.	0.991
pdam_00005042	pdam_00008166	A0A3M6T6M9	A0A3M6TC88	Uncharacterized protein.	SUEL-type lectin domain-containing protein.	0.991
pdam_00005042	pdam_00008942	A0A3M6T6M9	A0A3M6T7Q3	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.991
pdam_00005042	pdam_00010697	A0A3M6T6M9	A0A3M6T747	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.991
pdam_00005042	pdam_00017523	A0A3M6T6M9	A0A3M6TCK9	Uncharacterized protein.	SUEL-type lectin domain-containing protein.	0.991
pdam_00005042	pdam_00017524	A0A3M6T6M9	A0A3M6TCF1	Uncharacterized protein.	SUEL-type lectin domain-containing protein.	0.991
pdam_00005042	pdam_00018324	A0A3M6T6M9	A0A3M6U9T4	Uncharacterized protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.991
pdam_00005042	pdam_00021236	A0A3M6T6M9	A0A3M6TQB9	Uncharacterized protein.	G_PROTEIN_RECEP_F2_4 domain-containing protein.	0.991
pdam_00008166	pdam_00005042	A0A3M6TC88	A0A3M6T6M9	SUEL-type lectin domain-containing protein.	Uncharacterized protein.	0.991
pdam_00008942	pdam_00005042	A0A3M6T7Q3	A0A3M6T6M9	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.991
pdam_00010697	pdam_00005042	A0A3M6T747	A0A3M6T6M9	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.991
pdam_00017523	pdam_00005042	A0A3M6TCK9	A0A3M6T6M9	SUEL-type lectin domain-containing protein.	Uncharacterized protein.	0.991
pdam_00017524	pdam_00000901	A0A3M6TCF1	A0A3M6T6A1	SUEL-type lectin domain-containing protein.	Uncharacterized protein.	0.440
pdam_00017524	pdam_00005042	A0A3M6TCF1	A0A3M6T6M9	SUEL-type lectin domain-containing protein.	Uncharacterized protein.	0.991

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

12

PPI enrichment p-value:

1.8e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031929

TOR signaling

6 of 21

2.52

5.09

9.38e-11

GO:0018105

Peptidyl-serine phosphorylation

7 of 109

1.87

3.43

3.77e-09

GO:0038203

TORC2 signaling

3 of 5

2.84

2.52

2.46e-05

GO:0016310

Phosphorylation

11 of 577

1.35

2.32

1.49e-11

GO:0006468

Protein phosphorylation

9 of 443

1.37

2.16

4.64e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0106310

Protein serine kinase activity

7 of 168

1.68

2.71

5.95e-08

GO:0004674

Protein serine/threonine kinase activity

7 of 286

1.45

1.97

1.12e-06

GO:0043539

Protein serine/threonine kinase activator activity

2 of 25

1.97

0.84

0.0263

GO:0005524

ATP binding

7 of 1017

0.9

0.72

0.0017

GO:0043168

Anion binding

8 of 1573

0.77

0.61

0.0018

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031932

TORC2 complex

6 of 8

2.94

6.69

2.80e-13

GO:0031931

TORC1 complex

3 of 4

2.94

2.83

6.76e-06

GO:0140535

Intracellular protein-containing complex

7 of 464

1.24

1.46

7.83e-06

GO:0005654

Nucleoplasm

7 of 1531

0.73

0.47

0.0187

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11954

Mixed, incl. TOR complex, and Ribosomal protein S6 kinase activity

5 of 14

2.62

4.36

4.68e-09

CL:11959

TOR complex

4 of 5

2.97

4.02

4.03e-08

CL:1728

G beta:gamma signalling through PI3Kgamma

3 of 6

2.76

2.64

1.41e-05

CL:1601

Mixed, incl. SH2 domain superfamily, and Costimulation by the CD28 family

4 of 71

1.82

1.88

8.70e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04150

mTOR signaling pathway

8 of 135

1.84

4.08

6.23e-12

map04920

Adipocytokine signaling pathway

4 of 48

1.99

2.51

5.06e-06

map04012

ErbB signaling pathway

4 of 67

1.84

2.21

1.35e-05

map04140

Autophagy - animal

5 of 129

1.65

2.13

4.98e-06

map04371

Apelin signaling pathway

4 of 90

1.71

1.94

3.36e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389357

CD28 dependent PI3K/Akt signaling

8 of 16

2.76

8.64

1.10e-17

MAP-6804757

Regulation of TP53 Degradation

8 of 20

2.67

8.31

2.32e-17

MAP-6806003

Regulation of TP53 Expression and Degradation

8 of 21

2.65

8.27

2.32e-17

MAP-5218920

VEGFR2 mediated vascular permeability

8 of 22

2.63

8.22

2.32e-17

MAP-389356

CD28 co-stimulation

8 of 26

2.55

7.9

5.41e-17

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031932

TORC2 complex

5 of 8

2.86

5.11

2.77e-10

GOCC:0031931

TORC1 complex

2 of 3

2.89

1.39

0.0030

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

5 of 115

1.7

2.16

6.70e-06

KW-0067

ATP-binding

7 of 458

1.25

1.48

6.70e-06

KW-0418

Kinase

7 of 517

1.2

1.39

6.70e-06

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02259

FAT domain

2 of 4

2.76

1.02

0.0144

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017892

Protein kinase, C-terminal

4 of 23

2.31

2.49

1.58e-05

IPR014009

PIK-related kinase

3 of 5

2.84

2.4

4.10e-05

IPR003152

FATC domain

3 of 5

2.84

2.4

4.10e-05

IPR000961

AGC-kinase, C-terminal

4 of 37

2.1

2.2

4.10e-05

IPR036940

Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily

3 of 11

2.5

2.09

0.00013

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01343

The FATC domain is named after FRAP, ATM, TRRAP C-terminal (PMID:10782091). The solution structure of the FATC domain suggests it plays a role in redox-dependent structural and cellular stability (PMID:15772072).

3 of 5

2.84

2.61

1.64e-05

SM00133

Extension to Ser/Thr-type protein kinases

4 of 37

2.1

2.37

1.64e-05

SM00146

Phosphoinositide 3-kinase, catalytic domain

3 of 11

2.5

2.37

3.55e-05

SM00220

Serine/Threonine protein kinases, catalytic domain

4 of 140

1.52

1.33

0.00074

SM00233

Pleckstrin homology domain.

3 of 141

1.39

0.73

0.0268

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