pdam_00009431 protein (Pocillopora damicornis)

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Predicted Interactions

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Score

pdam_00009431

Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (74 aa)

Predicted Functional Partners:

pdam_00009630

0.531

pdam_00017181

0.498

pdam_00017896

0.476

pdam_00007633

0.471

pdam_00003538

0.471

pdam_00015792

0.428

pdam_00020945

0.419

pdam_00018185

0.405

Your Current Organism:

Pocillopora damicornis

NCBI taxonomy Id: 46731
Other names: P. damicornis, Pocillopora caespitosa laysanensis, Pocillopora damicornis laysanensis, cauliflower coral, lace coral

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
pdam_00003538	pdam_00009431	A0A3M6V6E9	A0A3M6TGI4	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.471
pdam_00003538	pdam_00009630	A0A3M6V6E9	A0A3M6U029	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.532
pdam_00003538	pdam_00018185	A0A3M6V6E9	A0A3M6TUJ2	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.517
pdam_00007633	pdam_00009431	A0A3M6TZJ6	A0A3M6TGI4	TGF_BETA_2 domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.471
pdam_00007633	pdam_00009630	A0A3M6TZJ6	A0A3M6U029	TGF_BETA_2 domain-containing protein.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.448
pdam_00009431	pdam_00003538	A0A3M6TGI4	A0A3M6V6E9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.471
pdam_00009431	pdam_00007633	A0A3M6TGI4	A0A3M6TZJ6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	TGF_BETA_2 domain-containing protein.	0.471
pdam_00009431	pdam_00009630	A0A3M6TGI4	A0A3M6U029	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.531
pdam_00009431	pdam_00015792	A0A3M6TGI4	A0A3M6UBX6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.428
pdam_00009431	pdam_00017181	A0A3M6TGI4	A0A3M6T571	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.498
pdam_00009431	pdam_00017896	A0A3M6TGI4	A0A3M6TDE2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.476
pdam_00009431	pdam_00018185	A0A3M6TGI4	A0A3M6TUJ2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.405
pdam_00009431	pdam_00020945	A0A3M6TGI4	A0A3M6TL36	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.419
pdam_00009630	pdam_00003538	A0A3M6U029	A0A3M6V6E9	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.532
pdam_00009630	pdam_00007633	A0A3M6U029	A0A3M6TZJ6	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	TGF_BETA_2 domain-containing protein.	0.448
pdam_00009630	pdam_00009431	A0A3M6U029	A0A3M6TGI4	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.531
pdam_00009630	pdam_00015792	A0A3M6U029	A0A3M6UBX6	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.489
pdam_00009630	pdam_00017181	A0A3M6U029	A0A3M6T571	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.402
pdam_00009630	pdam_00018185	A0A3M6U029	A0A3M6TUJ2	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.486
pdam_00015792	pdam_00009431	A0A3M6UBX6	A0A3M6TGI4	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.428

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.885

expected number of edges:

11

PPI enrichment p-value:

0.000195

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001732

Formation of cytoplasmic translation initiation complex

10 of 16

2.95

12.23

1.43e-24

GO:0006446

Regulation of translational initiation

3 of 19

2.35

2.27

4.70e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003743

Translation initiation factor activity

11 of 44

2.55

11.02

6.93e-25

GO:0031369

Translation initiation factor binding

2 of 20

2.15

0.89

0.0217

GO:0003723

RNA binding

5 of 678

1.02

0.65

0.0139

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033290

Eukaryotic 48S preinitiation complex

11 of 15

3.02

14.64

2.50e-29

GO:0005852

Eukaryotic translation initiation factor 3 complex

10 of 14

3.0

13.14

3.29e-26

GO:0016282

Eukaryotic 43S preinitiation complex

10 of 18

2.9

12.54

1.65e-25

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7924

Translation preinitiation complex

11 of 20

2.89

13.62

6.42e-28

CL:7926

Eukaryotic translation initiation factor 3 complex

10 of 12

3.07

13.34

2.54e-26

CL:7938

Eukaryotic translation initiation factor 3 complex

5 of 6

3.07

5.93

1.15e-11

CL:7927

Eukaryotic translation initiation factor 3 complex

5 of 6

3.07

5.93

1.15e-11

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

9 of 180

1.85

4.61

4.04e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

11 of 49

2.5

10.67

1.46e-24

MAP-72649

Translation initiation complex formation

11 of 56

2.44

10.29

2.74e-24

MAP-72702

Ribosomal scanning and start codon recognition

11 of 58

2.43

10.21

2.74e-24

MAP-72662

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

11 of 59

2.42

10.17

2.74e-24

MAP-156827

L13a-mediated translational silencing of Ceruloplasmin expression

11 of 102

2.18

8.15

4.95e-22

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005852

Eukaryotic translation initiation factor 3 complex

9 of 13

2.99

11.24

2.49e-22

GOCC:0071541

Eukaryotic translation initiation factor 3 complex, eIF3m

3 of 4

3.03

2.86

6.15e-06

GOCC:0071540

Eukaryotic translation initiation factor 3 complex, eIF3e

2 of 2

3.15

1.74

0.00073

GOCC:0043614

multi-eIF complex

2 of 2

3.15

1.74

0.00073

GOCC:0070993

Translation preinitiation complex

2 of 4

2.85

1.59

0.0013

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

8 of 19

2.77

9.11

1.14e-18

KW-0963

Cytoplasm

8 of 161

1.85

4.21

2.32e-12

KW-0694

RNA-binding

3 of 191

1.35

0.76

0.0194

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000717

Proteasome component (PCI) domain

4 of 18

2.5

2.87

3.75e-06

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

3 of 13

2.51

2.21

7.67e-05

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