pdam_00017707 protein (Pocillopora damicornis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

pdam_00017707

Uncharacterized protein. (181 aa)

Predicted Functional Partners:

pdam_00001560

0.876

pdam_00000532

0.778

pdam_00002288

0.760

pdam_00008063

0.703

pdam_00015683

0.703

pdam_00019418

0.703

pdam_00014230

0.703

pdam_00025437

0.703

pdam_00014466

0.703

pdam_00010549

0.703

Your Current Organism:

Pocillopora damicornis

NCBI taxonomy Id: 46731
Other names: P. damicornis, Pocillopora caespitosa laysanensis, Pocillopora damicornis laysanensis, cauliflower coral, lace coral

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
pdam_00000532	pdam_00001560	A0A3M6TY99	A0A3M6U5I9	Uncharacterized protein.	Uncharacterized protein.	0.943
pdam_00000532	pdam_00017707	A0A3M6TY99	A0A3M6TXY4	Uncharacterized protein.	Uncharacterized protein.	0.778
pdam_00001560	pdam_00000532	A0A3M6U5I9	A0A3M6TY99	Uncharacterized protein.	Uncharacterized protein.	0.943
pdam_00001560	pdam_00002288	A0A3M6U5I9	A0A3M6TFI2	Uncharacterized protein.	Ig-like domain-containing protein.	0.437
pdam_00001560	pdam_00008063	A0A3M6U5I9	A0A3M6TE76	Uncharacterized protein.	Uncharacterized protein.	0.657
pdam_00001560	pdam_00010549	A0A3M6U5I9	A0A3M6V537	Uncharacterized protein.	Uncharacterized protein.	0.657
pdam_00001560	pdam_00014230	A0A3M6U5I9	A0A3M6UGY4	Uncharacterized protein.	Uncharacterized protein.	0.657
pdam_00001560	pdam_00014466	A0A3M6U5I9	A0A3M6UZ14	Uncharacterized protein.	COR domain-containing protein.	0.657
pdam_00001560	pdam_00015683	A0A3M6U5I9	A0A3M6TZJ0	Uncharacterized protein.	Uncharacterized protein.	0.657
pdam_00001560	pdam_00017707	A0A3M6U5I9	A0A3M6TXY4	Uncharacterized protein.	Uncharacterized protein.	0.876
pdam_00001560	pdam_00019418	A0A3M6U5I9	A0A3M6U4Q4	Uncharacterized protein.	COR domain-containing protein.	0.657
pdam_00001560	pdam_00025437	A0A3M6U5I9	A0A3M6UW96	Uncharacterized protein.	COR domain-containing protein.	0.657
pdam_00002288	pdam_00001560	A0A3M6TFI2	A0A3M6U5I9	Ig-like domain-containing protein.	Uncharacterized protein.	0.437
pdam_00002288	pdam_00008063	A0A3M6TFI2	A0A3M6TE76	Ig-like domain-containing protein.	Uncharacterized protein.	0.987
pdam_00002288	pdam_00010549	A0A3M6TFI2	A0A3M6V537	Ig-like domain-containing protein.	Uncharacterized protein.	0.987
pdam_00002288	pdam_00014230	A0A3M6TFI2	A0A3M6UGY4	Ig-like domain-containing protein.	Uncharacterized protein.	0.987
pdam_00002288	pdam_00014466	A0A3M6TFI2	A0A3M6UZ14	Ig-like domain-containing protein.	COR domain-containing protein.	0.987
pdam_00002288	pdam_00015683	A0A3M6TFI2	A0A3M6TZJ0	Ig-like domain-containing protein.	Uncharacterized protein.	0.987
pdam_00002288	pdam_00017707	A0A3M6TFI2	A0A3M6TXY4	Ig-like domain-containing protein.	Uncharacterized protein.	0.760
pdam_00002288	pdam_00019418	A0A3M6TFI2	A0A3M6U4Q4	Ig-like domain-containing protein.	COR domain-containing protein.	0.987

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042073

Intraciliary transport

7 of 36

2.65

6.81

4.18e-14

GO:0044782

Cilium organization

9 of 272

1.89

4.55

3.11e-13

GO:0060271

Cilium assembly

8 of 250

1.87

4.11

1.24e-11

GO:1905515

Non-motile cilium assembly

4 of 37

2.4

3.21

6.11e-07

GO:0035720

Intraciliary anterograde transport

2 of 2

3.37

2.03

0.00022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0120170

Intraciliary transport particle B binding

2 of 2

3.37

1.48

0.0022

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030992

Intraciliary transport particle B

10 of 18

3.11

13.77

4.68e-27

GO:0036064

Ciliary basal body

7 of 102

2.2

5.28

1.82e-12

GO:0005929

Cilium

10 of 506

1.66

3.82

3.95e-14

GO:0005815

Microtubule organizing center

8 of 427

1.64

3.15

1.58e-10

GO:0097546

Ciliary base

3 of 17

2.61

2.82

5.55e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3185

Intraciliary transport particle B

10 of 12

3.29

14.44

8.60e-28

CL:3188

Intraciliary transport particle B

5 of 5

3.37

6.86

3.16e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5620924

Intraflagellar transport

10 of 63

2.57

10.1

2.76e-22

MAP-5617833

Cilium Assembly

10 of 311

1.87

5.09

6.12e-16

MAP-1852241

Organelle biogenesis and maintenance

10 of 355

1.82

4.75

1.50e-15

MAP-5610787

Hedgehog off state

4 of 126

1.87

1.96

6.78e-05

MAP-5358351

Signaling by Hedgehog

4 of 176

1.72

1.68

0.00020

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005929

Cilium

5 of 335

1.54

1.52

0.00022

GOCC:0097546

Ciliary base

2 of 8

2.76

1.45

0.0023

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019734

Tetratricopeptide repeat

4 of 122

1.88

1.5

0.00090

IPR011990

Tetratricopeptide-like helical domain superfamily

4 of 212

1.64

1.14

0.0039

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00028

Tetratricopeptide repeats

3 of 74

1.97

1.32

0.0026

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