| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SGO_0937 | cysE | SGO_0937 | SGO_0345 | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | 0.802 |
| SGO_0937 | glyA | SGO_0937 | SGO_1151 | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.900 |
| SGO_0937 | ilvA | SGO_0937 | SGO_0529 | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.901 |
| SGO_0937 | sdhA | SGO_0937 | SGO_0019 | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.900 |
| SGO_0937 | sdhB | SGO_0937 | SGO_0020 | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | L-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.900 |
| SGO_0937 | serB | SGO_0937 | SGO_1430 | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | Phosphoserine phosphatase SerB; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. | 0.906 |
| SGO_0937 | trpA-1 | SGO_0937 | SGO_0424 | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | Tryptophan synthase, alpha subunit; Identified by match to protein family HMM PF00290; match to protein family HMM TIGR00262. | 0.900 |
| SGO_0937 | trpA-2 | SGO_0937 | SGO_0663 | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.900 |
| SGO_0937 | trpB-1 | SGO_0937 | SGO_0662 | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| SGO_0937 | trpB-2 | SGO_0937 | SGO_0656 | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.900 |
| cysE | SGO_0937 | SGO_0345 | SGO_0937 | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | Phosphatidylserine synthase; Identified by match to protein family HMM PF01066. | 0.802 |
| cysE | glyA | SGO_0345 | SGO_1151 | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.833 |
| cysE | ilvA | SGO_0345 | SGO_0529 | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.812 |
| cysE | sdhA | SGO_0345 | SGO_0019 | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.906 |
| cysE | sdhB | SGO_0345 | SGO_0020 | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | L-serine dehydratase, iron-sulfur-dependent, beta subunit; Identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.906 |
| cysE | serB | SGO_0345 | SGO_1430 | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | Phosphoserine phosphatase SerB; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR00338; match to protein family HMM TIGR01488. | 0.857 |
| cysE | trpA-1 | SGO_0345 | SGO_0424 | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | Tryptophan synthase, alpha subunit; Identified by match to protein family HMM PF00290; match to protein family HMM TIGR00262. | 0.805 |
| cysE | trpA-2 | SGO_0345 | SGO_0663 | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.805 |
| cysE | trpB-1 | SGO_0345 | SGO_0662 | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.805 |
| cysE | trpB-2 | SGO_0345 | SGO_0656 | Serine O-acetyltransferase; Identified by match to protein family HMM TIGR01172. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.805 |
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