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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SGO_0111Identified by match to protein family HMM PF02493. (137 aa)    
Predicted Functional Partners:
SGO_0112
Putative acyltransferase; Identified by match to protein family HMM PF01757.
 
     0.876
SGO_0110
Phosphotyrosine protein phosphatase; Identified by match to protein family HMM PF01451; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
  
    0.806
SGO_0599
Phosphoprotein phosphatase; Identified by match to protein family HMM PF00481.
    
   0.546
mutT
Identified by match to protein family HMM PF00293.
  
     0.539
SGO_1839
Conserved hypothetical protein.
   
 0.525
dnaJ
DnaJ chaparone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
    
 
 0.497
ruvB
Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
       0.493
acdH
Alcohol-acetaldehyde dehydrogenase; Identified by match to protein family HMM PF00171; match to protein family HMM PF00465; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
       0.474
gmk
Guanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP.
    
   0.474
SGO_0109
Bacterial protein of unknown function (DUF925) superfamily; Identified by match to protein family HMM PF06042.
       0.456
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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