| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SGO_0747 | SGO_1636 | SGO_0747 | SGO_1636 | Putative methionine synthase. | Cystathionine gamma-synthase; Identified by match to protein family HMM PF00202; match to protein family HMM PF01053. | 0.952 |
| SGO_0747 | metA | SGO_0747 | SGO_1002 | Putative methionine synthase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.443 |
| SGO_0747 | metE | SGO_0747 | SGO_0310 | Putative methionine synthase. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.932 |
| SGO_0747 | metF | SGO_0747 | SGO_0311 | Putative methionine synthase. | 5,10-methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.720 |
| SGO_0747 | metK | SGO_0747 | SGO_0987 | Putative methionine synthase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.957 |
| SGO_1636 | SGO_0747 | SGO_1636 | SGO_0747 | Cystathionine gamma-synthase; Identified by match to protein family HMM PF00202; match to protein family HMM PF01053. | Putative methionine synthase. | 0.952 |
| SGO_1636 | metA | SGO_1636 | SGO_1002 | Cystathionine gamma-synthase; Identified by match to protein family HMM PF00202; match to protein family HMM PF01053. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.964 |
| SGO_1636 | metE | SGO_1636 | SGO_0310 | Cystathionine gamma-synthase; Identified by match to protein family HMM PF00202; match to protein family HMM PF01053. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.964 |
| SGO_1636 | metF | SGO_1636 | SGO_0311 | Cystathionine gamma-synthase; Identified by match to protein family HMM PF00202; match to protein family HMM PF01053. | 5,10-methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.820 |
| fhs-1 | fhs-2 | SGO_1210 | SGO_1808 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.902 |
| fhs-1 | folD | SGO_1210 | SGO_0690 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
| fhs-1 | glyA | SGO_1210 | SGO_1151 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.979 |
| fhs-1 | metA | SGO_1210 | SGO_1002 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.656 |
| fhs-1 | metE | SGO_1210 | SGO_0310 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.754 |
| fhs-1 | metF | SGO_1210 | SGO_0311 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.725 |
| fhs-1 | metK | SGO_1210 | SGO_0987 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.680 |
| fhs-1 | thyA | SGO_1210 | SGO_1143 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.648 |
| fhs-2 | fhs-1 | SGO_1808 | SGO_1210 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.902 |
| fhs-2 | folD | SGO_1808 | SGO_0690 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
| fhs-2 | glyA | SGO_1808 | SGO_1151 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.979 |
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