Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
SGO_0486Identified by match to protein family HMM PF04607. (208 aa)    
Predicted Functional Partners:
SGO_0484
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF02518.
 
     0.958
SGO_0485
DNA-binding response regulator; Identified by match to protein family HMM PF00072.
     0.929
SGO_1222
GTP pyrophosphokinase-like protein; Identified by match to protein family HMM PF04607.
  
  
 
0.920
relA
GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
    
 0.920
nrdD
Ribonucleoside-triphosphate reductase; Identified by match to protein family HMM PF01228; match to protein family HMM PF03477; match to protein family HMM TIGR02487.
     
  0.900
folE
GTP cyclohydrolase I; Identified by match to protein family HMM PF01227; match to protein family HMM TIGR00063.
     
  0.800
trmE
tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
   
    0.561
dgkA
Diacylglycerol kinase (DAGK) (Diglyceride kinase)(DGK); Identified by match to protein family HMM PF01219.
     
  0.500
SGO_0487
Phosphorylase, Pnp/Udp family.
       0.482
SGO_0488
ABC transporter, ATP-binding protein SP0483; Identified by match to protein family HMM PF00005.
       0.473
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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