close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING newly available directed regulatory networks a new typed view showing functional, physical, and regulatory edges in one network new clustering options and cluster-based layouts … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sgcSerine protease challisin; Identified by match to protein family HMM PF00082; match to protein family HMM PF02225; match to protein family HMM PF04650; match to protein family HMM PF06280; match to protein family HMM PF07554; match to protein family HMM TIGR01168. (1513 aa)    
Predicted Functional Partners:
hisS
histidyl-tRNA synthetase; Identified by match to protein family HMM PF00587; match to protein family HMM PF03129; match to protein family HMM TIGR00442.
   
  
 0.626
SGO_0427
Identified by match to protein family HMM PF00582.
   
  
 0.575
SGO_0707
LPXTG cell wall surface protein; Identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167.
 
 
 0.575
spxB
Pyruvate oxidase; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720; Belongs to the TPP enzyme family.
      
 0.574
act
Pyruvate formate-lyase-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.
      
 0.573
pflC
Formate acetyltransferase activating enzyme; Identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494.
      
 0.573
comX
ComX.
      
 0.571
argC
N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
      
 0.545
zmpB
Zinc metalloproteinase B; Identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168.
 
  
 0.539
zmpC
Zinc metalloproteinase C; Identified by match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07554; match to protein family HMM PF07580; match to protein family HMM PF07581; match to protein family HMM TIGR01168.
 
  
 0.489
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
Server load: medium (44%) [HD]