| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CtsR | SGO_0688 | SGO_1999 | SGO_0688 | Transcription regulator ctsR; Identified by match to protein family HMM PF05848; Belongs to the CtsR family. | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 0.548 |
| CtsR | clpP | SGO_1999 | SGO_1632 | Transcription regulator ctsR; Identified by match to protein family HMM PF05848; Belongs to the CtsR family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.713 |
| CtsR | dnaK | SGO_1999 | SGO_0402 | Transcription regulator ctsR; Identified by match to protein family HMM PF05848; Belongs to the CtsR family. | DnaK chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.708 |
| CtsR | groES | SGO_1999 | SGO_1886 | Transcription regulator ctsR; Identified by match to protein family HMM PF05848; Belongs to the CtsR family. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.727 |
| CtsR | groL | SGO_1999 | SGO_1885 | Transcription regulator ctsR; Identified by match to protein family HMM PF05848; Belongs to the CtsR family. | 60 kDa chaperonin/groEL protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.514 |
| CtsR | grpE | SGO_1999 | SGO_0401 | Transcription regulator ctsR; Identified by match to protein family HMM PF05848; Belongs to the CtsR family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.583 |
| SGO_0688 | CtsR | SGO_0688 | SGO_1999 | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Transcription regulator ctsR; Identified by match to protein family HMM PF05848; Belongs to the CtsR family. | 0.548 |
| SGO_0688 | SGO_0689 | SGO_0688 | SGO_0689 | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Conserved hypothetical protein; Identified by match to protein family HMM PF08796. | 0.517 |
| SGO_0688 | SGO_1768 | SGO_0688 | SGO_1768 | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Glycosyl hydrolase, family 38; Identified by match to protein family HMM PF01074; match to protein family HMM PF07748. | 0.461 |
| SGO_0688 | clpP | SGO_0688 | SGO_1632 | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.869 |
| SGO_0688 | dnaJ | SGO_0688 | SGO_0404 | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | DnaJ chaparone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.716 |
| SGO_0688 | dnaK | SGO_0688 | SGO_0402 | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | DnaK chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.879 |
| SGO_0688 | groES | SGO_0688 | SGO_1886 | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.547 |
| SGO_0688 | groL | SGO_0688 | SGO_1885 | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 60 kDa chaperonin/groEL protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.514 |
| SGO_0688 | grpE | SGO_0688 | SGO_0401 | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.627 |
| SGO_0688 | mecA | SGO_0688 | SGO_1724 | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | Adapter protein mec; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | 0.731 |
| SGO_0689 | SGO_0688 | SGO_0689 | SGO_0688 | Conserved hypothetical protein; Identified by match to protein family HMM PF08796. | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 0.517 |
| SGO_1768 | SGO_0688 | SGO_1768 | SGO_0688 | Glycosyl hydrolase, family 38; Identified by match to protein family HMM PF01074; match to protein family HMM PF07748. | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 0.461 |
| clpP | CtsR | SGO_1632 | SGO_1999 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Transcription regulator ctsR; Identified by match to protein family HMM PF05848; Belongs to the CtsR family. | 0.713 |
| clpP | SGO_0688 | SGO_1632 | SGO_0688 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP dependent Clp protease, ATP-binding subunit, ClpE; Identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; Belongs to the ClpA/ClpB family. | 0.869 |
STRING v12.5 is now available!
