node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SGO_0160 | SGO_1807 | SGO_0160 | SGO_1807 | Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. | 0.924 |
SGO_0160 | folD | SGO_0160 | SGO_0690 | Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |
SGO_0160 | glyA | SGO_0160 | SGO_1151 | Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.447 |
SGO_0160 | purN | SGO_0160 | SGO_0038 | Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.923 |
SGO_1807 | SGO_0160 | SGO_1807 | SGO_0160 | Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. | Identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.924 |
SGO_1807 | fhs-1 | SGO_1807 | SGO_1210 | Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.916 |
SGO_1807 | fhs-2 | SGO_1807 | SGO_1808 | Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.965 |
SGO_1807 | fmt | SGO_1807 | SGO_0597 | Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.912 |
SGO_1807 | folD | SGO_1807 | SGO_0690 | Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |
SGO_1807 | purH | SGO_1807 | SGO_0040 | Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.903 |
SGO_1807 | purN | SGO_1807 | SGO_0038 | Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.906 |
fhs-1 | SGO_1807 | SGO_1210 | SGO_1807 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. | 0.916 |
fhs-1 | fhs-2 | SGO_1210 | SGO_1808 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.902 |
fhs-1 | folD | SGO_1210 | SGO_0690 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
fhs-1 | glyA | SGO_1210 | SGO_1151 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.979 |
fhs-1 | metF | SGO_1210 | SGO_0311 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylenetetrahydrofolate reductase; Identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.725 |
fhs-1 | purH | SGO_1210 | SGO_0040 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.961 |
fhs-1 | purN | SGO_1210 | SGO_0038 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.948 |
fhs-1 | thyA | SGO_1210 | SGO_1143 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.648 |
fhs-2 | SGO_1807 | SGO_1808 | SGO_1807 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine cycle enzyme, putative; Identified by match to protein family HMM PF04961. | 0.965 |