Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SGO_0705Protein of unknown function (DUF1250) superfamily; Identified by match to protein family HMM PF06855; Belongs to the UPF0346 family. (77 aa)    
Predicted Functional Partners:
SGO_0706
Identified by match to protein family HMM PF00013; match to protein family HMM PF02562.
       0.737
SGO_0852
TPR domain protein; Identified by similarity to GB:AAO81340.1; match to protein family HMM PF00515.
  
     0.586
gpmA
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
       0.536
SGO_0588
Conserved hypothetical protein; Identified by match to protein family HMM PF06908; Belongs to the UPF0398 family.
  
     0.477
SGO_1450
Conserved hypothetical protein; Belongs to the CvfB family.
     
 0.462
frr
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
       0.455
pyrH
Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP.
       0.455
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.452
SGO_0220
Protein of unknown function (DUF1447) superfamily; Identified by match to protein family HMM PF07288; Belongs to the UPF0356 family.
  
   
 0.427
SGO_1585
D-Alanyl-D-Alanine carboxypeptidase; Identified by match to protein family HMM PF00768; Belongs to the peptidase S11 family.
       0.427
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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