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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SGO_0779Response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486. (233 aa)    
Predicted Functional Partners:
SGO_0780
Histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229.
 0.997
SGO_1180
Histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
 
 0.905
vicX
Zn-dependent hydrolase (beta-lactamase superfamily); Identified by match to protein family HMM PF00753.
  
  
 0.897
SGO_1907
Sensor protein; Identified by match to protein family HMM PF00512; match to protein family HMM PF02518.
 
 
 0.865
SGO_1073
Sensor protein CiaH; Identified by match to protein family HMM PF00512; match to protein family HMM PF02518.
 
 
 0.860
SGO_0299
Putative histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF02518.
 
 
 0.839
SGO_1416
Putative histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518.
 
 0.786
SGO_0782
Protein of unknown function (DUF454) family; Identified by match to protein family HMM PF04304.
       0.699
SGO_1504
Histidine kinase; Identified by match to protein family HMM PF02518.
 
 0.686
SGO_0484
Sensor histidine kinase; Identified by match to protein family HMM PF00512; match to protein family HMM PF02518.
 
 
 0.667
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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