node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SGO_0354 | SGO_0908 | SGO_0354 | SGO_0908 | Membrane spanning protein; Identified by match to protein family HMM PF06081. | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | 0.420 |
SGO_0908 | SGO_0354 | SGO_0908 | SGO_0354 | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | Membrane spanning protein; Identified by match to protein family HMM PF06081. | 0.420 |
SGO_0908 | SGO_0911 | SGO_0908 | SGO_0911 | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | Conserved hypothetical protein; Belongs to the SUA5 family. | 0.577 |
SGO_0908 | leuA | SGO_0908 | SGO_0906 | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.804 |
SGO_0908 | leuB | SGO_0908 | SGO_0907 | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.832 |
SGO_0908 | leuC | SGO_0908 | SGO_0909 | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.800 |
SGO_0908 | leuD | SGO_0908 | SGO_0910 | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.790 |
SGO_0908 | topA | SGO_0908 | SGO_1197 | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.483 |
SGO_0911 | SGO_0908 | SGO_0911 | SGO_0908 | Conserved hypothetical protein; Belongs to the SUA5 family. | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | 0.577 |
SGO_0911 | leuA | SGO_0911 | SGO_0906 | Conserved hypothetical protein; Belongs to the SUA5 family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.571 |
SGO_0911 | leuB | SGO_0911 | SGO_0907 | Conserved hypothetical protein; Belongs to the SUA5 family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.648 |
SGO_0911 | leuC | SGO_0911 | SGO_0909 | Conserved hypothetical protein; Belongs to the SUA5 family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.635 |
SGO_0911 | leuD | SGO_0911 | SGO_0910 | Conserved hypothetical protein; Belongs to the SUA5 family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.662 |
SGO_0911 | topA | SGO_0911 | SGO_1197 | Conserved hypothetical protein; Belongs to the SUA5 family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.437 |
leuA | SGO_0908 | SGO_0906 | SGO_0908 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | 0.804 |
leuA | SGO_0911 | SGO_0906 | SGO_0911 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | Conserved hypothetical protein; Belongs to the SUA5 family. | 0.571 |
leuA | leuB | SGO_0906 | SGO_0907 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.997 |
leuA | leuC | SGO_0906 | SGO_0909 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.999 |
leuA | leuD | SGO_0906 | SGO_0910 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.999 |
leuB | SGO_0908 | SGO_0907 | SGO_0908 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | Predicted membrane protein of unknown function (DUF1294); Identified by match to protein family HMM PF06961. | 0.832 |