Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cutCCopper homeostasis protein CutC; Participates in the control of copper homeostasis. Belongs to the CutC family. (210 aa)    
Predicted Functional Partners:
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
    
   0.703
SGO_0960
Protein of unknown function (DUF419) family; Identified by match to protein family HMM PF04237.
  
    0.687
SGO_0957
Conserved hypothetical protein.
       0.603
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.583
SGO_1422
Conserved hypothetical protein.
  
    0.575
SGO_0958
Conserved hypothetical protein.
       0.566
SGO_0961
ABC transporter, permease/ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.
       0.506
SGO_0962
ABC transporter, permease/ATP-binding protein; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.
       0.506
SGO_0281
PTS system, beta-glucoside-specific IIABC component; Identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830; match to protein family HMM TIGR01995.
     
 0.502
SGO_0505
PTS system, IIBC component; Identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR02003.
     
 0.502
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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