| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SGO_0096 | SGO_0981 | SGO_0096 | SGO_0981 | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | comE operon protein 2 family; Identified by match to protein family HMM PF00383. | 0.908 |
| SGO_0096 | SGO_1263 | SGO_0096 | SGO_1263 | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.910 |
| SGO_0096 | cdd | SGO_0096 | SGO_1081 | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.900 |
| SGO_0096 | deoD | SGO_0096 | SGO_1260 | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. | 0.901 |
| SGO_0096 | dut | SGO_0096 | SGO_0169 | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
| SGO_0096 | pdp | SGO_0096 | SGO_1079 | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | Pyrimidine-nucleoside phosphorylase; Identified by match to protein family HMM PF00591; match to protein family HMM PF02885; match to protein family HMM PF07831; match to protein family HMM TIGR02644. | 0.902 |
| SGO_0096 | tdk | SGO_0096 | SGO_1155 | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | Thymidine kinase; Identified by match to protein family HMM PF00265. | 0.902 |
| SGO_0096 | thyA | SGO_0096 | SGO_1143 | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
| SGO_0096 | tmk | SGO_0096 | SGO_1539 | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.902 |
| SGO_0981 | SGO_0096 | SGO_0981 | SGO_0096 | comE operon protein 2 family; Identified by match to protein family HMM PF00383. | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | 0.908 |
| SGO_0981 | dut | SGO_0981 | SGO_0169 | comE operon protein 2 family; Identified by match to protein family HMM PF00383. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.946 |
| SGO_0981 | pdp | SGO_0981 | SGO_1079 | comE operon protein 2 family; Identified by match to protein family HMM PF00383. | Pyrimidine-nucleoside phosphorylase; Identified by match to protein family HMM PF00591; match to protein family HMM PF02885; match to protein family HMM PF07831; match to protein family HMM TIGR02644. | 0.556 |
| SGO_0981 | tdk | SGO_0981 | SGO_1155 | comE operon protein 2 family; Identified by match to protein family HMM PF00383. | Thymidine kinase; Identified by match to protein family HMM PF00265. | 0.927 |
| SGO_0981 | thyA | SGO_0981 | SGO_1143 | comE operon protein 2 family; Identified by match to protein family HMM PF00383. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.940 |
| SGO_0981 | tmk | SGO_0981 | SGO_1539 | comE operon protein 2 family; Identified by match to protein family HMM PF00383. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.927 |
| SGO_1263 | SGO_0096 | SGO_1263 | SGO_0096 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Conserved hypothetical protein; Identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; match to protein family HMM TIGR01549. | 0.910 |
| SGO_1263 | cdd | SGO_1263 | SGO_1081 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.920 |
| SGO_1263 | deoD | SGO_1263 | SGO_1260 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Purine nucleoside phosphorylase; Identified by match to protein family HMM PF01048; match to protein family HMM TIGR00107. | 0.956 |
| SGO_1263 | pdp | SGO_1263 | SGO_1079 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Pyrimidine-nucleoside phosphorylase; Identified by match to protein family HMM PF00591; match to protein family HMM PF02885; match to protein family HMM PF07831; match to protein family HMM TIGR02644. | 0.927 |
| SGO_1263 | tdk | SGO_1263 | SGO_1155 | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | Thymidine kinase; Identified by match to protein family HMM PF00265. | 0.910 |
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