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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SGO_1225Pyridoxal-phosphate dependent aminotransferase; Identified by match to protein family HMM PF00266. (375 aa)    
Predicted Functional Partners:
SGO_1719
SUF system FeS assembly protein, NifU family; Identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994.
 
 0.991
thiI
Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
 0.963
SGO_1226
Conserved hypothetical protein; Identified by match to protein family HMM PF08866.
  
 
 0.940
SGO_0814
Aminotransferase, class-V; Identified by match to protein family HMM PF00266.
  
  
 
0.915
prs
Ribose-phosphate pyrophosphokinase 2; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
    0.797
SGO_1227
Conserved hypothetical protein.
       0.699
dnaK
DnaK chaperone protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
  
 0.669
SGO_0731
Identified by match to protein family HMM PF02082.
  
  
 0.647
SGO_1223
Adenylate cyclase; Identified by match to protein family HMM PF01928.
       0.634
SGO_1720
Aminotransferase, class-V; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.
    
0.580
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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