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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SGO_1365Transcription regulator yrfE; Identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350. (443 aa)    
Predicted Functional Partners:
pheA
Prephenate dehydratase; Identified by match to protein family HMM PF00800; match to protein family HMM PF01842.
 
   
 0.817
aroK
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
     
 0.788
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
       0.777
codY
GTP-sensing transcriptional pleiotropic repressor codY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
  
   
 0.630
wzg
Transcriptional regulator; Identified by match to protein family HMM PF02916; match to protein family HMM PF03816; match to protein family HMM TIGR00350.
  
   
 0.584
rumA-2
23S rRNA (uracil-5-)-methyltransferase RumA; Identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.
  
    0.567
SGO_1114
Protein of unknown function (DUF1149) superfamily; Identified by match to protein family HMM PF06619.
  
     0.562
SGO_1925
Putative DNA binding protein; Identified by match to protein family HMM PF06279.
  
     0.540
SGO_1369
L-2-hydroxyisocaproate dehydrogenase; Identified by match to protein family HMM PF00056; match to protein family HMM PF02866; Belongs to the LDH/MDH superfamily.
       0.490
SGO_0029
Conserved hypothetical protein; Identified by match to protein family HMM PF06257.
  
     0.480
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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