close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
manAMannose-6-phosphate isomerase, class I; Identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218; Belongs to the mannose-6-phosphate isomerase type 1 family. (314 aa)    
Predicted Functional Partners:
scrK
Fructokinase; Identified by match to protein family HMM PF00480.
 
 
 0.978
SGO_1679
Phosphotransferase system enzyme II; Identified by match to protein family HMM PF03610; match to protein family HMM PF03830.
 
  
 0.958
pfkA
Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
    
 0.950
pgi
Glucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family.
 
 
 0.949
glmS
Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
  
 
 0.948
nagB
Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
     
 0.947
fbp
Fructose-bisphosphatase; Identified by match to protein family HMM PF06874.
  
  
 0.944
SGO_1680
Phosphotransferase system enzyme II; Identified by match to protein family HMM PF03609.
 
  
  0.930
SGO_1681
PTS system, mannose/fructose/sorbose family, IID component; Identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828.
 
  
  0.925
SGO_0047
PTS system, IIA component; Identified by match to protein family HMM PF03610.
    
 0.908
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.