Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
comECompetence response regulator ComE; Identified by match to protein family HMM PF00072; match to protein family HMM PF04397. (255 aa)    
Predicted Functional Partners:
comD
Histidine protein kinase ComD; Identified by match to protein family HMM PF02518.
 
 
 0.998
comC
Competence factor-related protein ComC; Identified by match to protein family HMM PF03047; match to protein family HMM TIGR01847.
     
 0.874
comB
Transport protein ComB; Identified by match to protein family HMM TIGR01000.
     
 0.725
comX
ComX.
      
 0.640
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
      
 0.612
rgg
Transcriptional regulator Rgg; Regulates the expression of glucosyltransferase (gtfG).
   
  
 0.601
comFA
Competence ComFA-like protein; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271.
      
 0.578
luxS
Autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
      
 0.572
SGO_1417
Response regulator protein; Identified by match to protein family HMM PF00072; match to protein family HMM PF00486.
      
 0.549
SGO_1750
ABC-type multidrug/protein/lipid transport system, ATPase component; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.
      
 0.531
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
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