close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
comECompetence response regulator ComE; Identified by match to protein family HMM PF00072; match to protein family HMM PF04397. (255 aa)    
Predicted Functional Partners:
comD
Histidine protein kinase ComD; Identified by match to protein family HMM PF02518.
 
 
 0.998
comC
Competence factor-related protein ComC; Identified by match to protein family HMM PF03047; match to protein family HMM TIGR01847.
     
 0.885
comB
Transport protein ComB; Identified by match to protein family HMM TIGR01000.
     
 0.659
comX
ComX.
      
 0.649
luxS
Autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
      
 0.600
comFA
Competence ComFA-like protein; Identified by match to protein family HMM PF00270; match to protein family HMM PF00271.
      
 0.593
DivIB
Cell division protein DivIB; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily.
      
 0.576
nusG
Transcription termination/antitermination factor NusG; Participates in transcription elongation, termination and antitermination.
   
  
 0.576
rgg
Transcriptional regulator Rgg; Regulates the expression of glucosyltransferase (gtfG).
      
 0.574
SGO_1750
ABC-type multidrug/protein/lipid transport system, ATPase component; Identified by match to protein family HMM PF00005; match to protein family HMM PF00664.
      
 0.572
Your Current Organism:
Streptococcus gordonii
NCBI taxonomy Id: 467705
Other names: S. gordonii str. Challis substr. CH1, Streptococcus gordonii ATCC 35105, Streptococcus gordonii str. Challis substr. CH1, Streptococcus gordonii str. Challis substr. DL1, Streptococcus gordonii str. Challis substr. V288
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.