FGIG_05570 protein (Fasciola gigantica) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

FGIG_05570

Mushroom body large-type Kenyon cell-specific protein 1. (574 aa)

Predicted Functional Partners:

FGIG_06261

0.588

FGIG_12055

0.520

FGIG_09650

0.520

FGIG_01928

0.509

FGIG_03401

0.483

FGIG_10179

0.467

FGIG_09483

0.451

FGIG_04036

0.445

FGIG_08645

0.445

FGIG_01387

0.400

Your Current Organism:

Fasciola gigantica

NCBI taxonomy Id: 46835
Other names: F. gigantica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGIG_01387	FGIG_05570	A0A504YXH1	A0A504Y4Y7	Homeobox protein Hox-D10.	Mushroom body large-type Kenyon cell-specific protein 1.	0.400
FGIG_01928	FGIG_04036	A0A504Z4P1	A0A504Y754	Enhancer of zeste.	Histone-lysine N-methyltransferase SETMAR.	0.894
FGIG_01928	FGIG_05570	A0A504Z4P1	A0A504Y4Y7	Enhancer of zeste.	Mushroom body large-type Kenyon cell-specific protein 1.	0.509
FGIG_01928	FGIG_08645	A0A504Z4P1	A0A504Z5B8	Enhancer of zeste.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.934
FGIG_01928	FGIG_10179	A0A504Z4P1	A0A504YCV5	Enhancer of zeste.	VEFS-Box domain-containing protein.	0.995
FGIG_03401	FGIG_05570	A0A504Y514	A0A504Y4Y7	Zinc finger C2CH type.	Mushroom body large-type Kenyon cell-specific protein 1.	0.483
FGIG_04036	FGIG_01928	A0A504Y754	A0A504Z4P1	Histone-lysine N-methyltransferase SETMAR.	Enhancer of zeste.	0.894
FGIG_04036	FGIG_05570	A0A504Y754	A0A504Y4Y7	Histone-lysine N-methyltransferase SETMAR.	Mushroom body large-type Kenyon cell-specific protein 1.	0.445
FGIG_04036	FGIG_10179	A0A504Y754	A0A504YCV5	Histone-lysine N-methyltransferase SETMAR.	VEFS-Box domain-containing protein.	0.828
FGIG_05570	FGIG_01387	A0A504Y4Y7	A0A504YXH1	Mushroom body large-type Kenyon cell-specific protein 1.	Homeobox protein Hox-D10.	0.400
FGIG_05570	FGIG_01928	A0A504Y4Y7	A0A504Z4P1	Mushroom body large-type Kenyon cell-specific protein 1.	Enhancer of zeste.	0.509
FGIG_05570	FGIG_03401	A0A504Y4Y7	A0A504Y514	Mushroom body large-type Kenyon cell-specific protein 1.	Zinc finger C2CH type.	0.483
FGIG_05570	FGIG_04036	A0A504Y4Y7	A0A504Y754	Mushroom body large-type Kenyon cell-specific protein 1.	Histone-lysine N-methyltransferase SETMAR.	0.445
FGIG_05570	FGIG_06261	A0A504Y4Y7	A0A504YZ57	Mushroom body large-type Kenyon cell-specific protein 1.	Condensin complex subunit 3.	0.588
FGIG_05570	FGIG_08645	A0A504Y4Y7	A0A504Z5B8	Mushroom body large-type Kenyon cell-specific protein 1.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.445
FGIG_05570	FGIG_09483	A0A504Y4Y7	A0A504Z2K1	Mushroom body large-type Kenyon cell-specific protein 1.	D-3-phosphoglycerate dehydrogenase.	0.451
FGIG_05570	FGIG_09650	A0A504Y4Y7	A0A504YQB1	Mushroom body large-type Kenyon cell-specific protein 1.	Subfamily S1B unassigned peptidase S01 family.	0.520
FGIG_05570	FGIG_10179	A0A504Y4Y7	A0A504YCV5	Mushroom body large-type Kenyon cell-specific protein 1.	VEFS-Box domain-containing protein.	0.467
FGIG_05570	FGIG_12055	A0A504Y4Y7	A0A504YMB7	Mushroom body large-type Kenyon cell-specific protein 1.	C-terminal binding protein 1.	0.520
FGIG_06261	FGIG_05570	A0A504YZ57	A0A504Y4Y7	Condensin complex subunit 3.	Mushroom body large-type Kenyon cell-specific protein 1.	0.588

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.803

expected number of edges:

12

PPI enrichment p-value:

3.55e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006468

Protein phosphorylation

5 of 144

1.52

1.46

0.00028

GO:0035556

Intracellular signal transduction

5 of 163

1.46

1.41

0.00030

GO:0007165

Signal transduction

6 of 243

1.37

1.33

0.00025

GO:0031929

TOR signaling

2 of 7

2.43

1.04

0.0125

GO:0010506

Regulation of autophagy

2 of 11

2.23

0.91

0.0208

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004674

Protein serine/threonine kinase activity

5 of 112

1.62

1.7

0.00010

GO:0005524

ATP binding

6 of 611

0.97

0.73

0.0036

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031931

TORC1 complex

2 of 3

2.8

1.16

0.0079

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2768

Mixed, incl. MTOR signalling, and TOR complex

7 of 17

2.59

6.61

6.83e-14

CL:2788

Mixed, incl. KA1 domain/Ssp2, C-terminal, and Nucleotide-activated protein kinase complex

4 of 7

2.73

3.87

5.80e-08

CL:2771

TOR complex, and 3-5 exonuclease

2 of 6

2.5

1.2

0.0063

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04136

Autophagy - other

3 of 25

2.05

1.8

0.00028

map04138

Autophagy - yeast

4 of 89

1.63

1.56

0.00028

map04139

Mitophagy - yeast

2 of 34

1.74

0.78

0.0306

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-380972

Energy dependent regulation of mTOR by LKB1-AMPK

3 of 11

2.41

1.88

0.00030

MAP-165159

MTOR signalling

3 of 15

2.28

1.83

0.00033

MAP-200425

Carnitine metabolism

2 of 5

2.58

1.36

0.0033

MAP-9006925

Intracellular signaling by second messengers

3 of 39

1.86

1.26

0.0031

MAP-9612973

Autophagy

3 of 48

1.77

1.22

0.0033

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011009

Protein kinase-like domain superfamily

5 of 143

1.52

1.36

0.00059

IPR000719

Protein kinase domain

4 of 114

1.52

1.01

0.0061

IPR017441

Protein kinase, ATP binding site

3 of 47

1.78

0.94

0.0140

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