FGIG_03833 protein (Fasciola gigantica) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

FGIG_03833

Serine/threonine-protein kinase MARK2. (203 aa)

Predicted Functional Partners:

FGIG_03075

0.736

FGIG_00155

0.699

FGIG_12213

0.699

FGIG_12158

0.699

FGIG_05814

0.699

FGIG_12079

0.699

FGIG_07351

0.699

FGIG_11567

0.651

FGIG_01864

0.651

FGIG_06233

0.628

Your Current Organism:

Fasciola gigantica

NCBI taxonomy Id: 46835
Other names: F. gigantica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGIG_00155	FGIG_03075	A0A504WSS7	A0A504YY59	14_3_3 domain-containing protein.	Kinase suppressor of Ras 2.	0.766
FGIG_00155	FGIG_03833	A0A504WSS7	A0A504YKQ3	14_3_3 domain-containing protein.	Serine/threonine-protein kinase MARK2.	0.699
FGIG_00155	FGIG_06233	A0A504WSS7	A0A504YFY0	14_3_3 domain-containing protein.	Connector enhancer of kinase suppressor of ras 2.	0.524
FGIG_01864	FGIG_03075	A0A504YSK0	A0A504YY59	SH3 and multiple ankyrin repeat domains protein 3.	Kinase suppressor of Ras 2.	0.442
FGIG_01864	FGIG_03833	A0A504YSK0	A0A504YKQ3	SH3 and multiple ankyrin repeat domains protein 3.	Serine/threonine-protein kinase MARK2.	0.651
FGIG_01864	FGIG_11567	A0A504YSK0	A0A504Y777	SH3 and multiple ankyrin repeat domains protein 3.	PDZ domain-containing protein.	0.815
FGIG_03075	FGIG_00155	A0A504YY59	A0A504WSS7	Kinase suppressor of Ras 2.	14_3_3 domain-containing protein.	0.766
FGIG_03075	FGIG_01864	A0A504YY59	A0A504YSK0	Kinase suppressor of Ras 2.	SH3 and multiple ankyrin repeat domains protein 3.	0.442
FGIG_03075	FGIG_03833	A0A504YY59	A0A504YKQ3	Kinase suppressor of Ras 2.	Serine/threonine-protein kinase MARK2.	0.736
FGIG_03075	FGIG_05814	A0A504YY59	A0A504YKJ3	Kinase suppressor of Ras 2.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide; Belongs to the 14-3-3 family.	0.766
FGIG_03075	FGIG_06233	A0A504YY59	A0A504YFY0	Kinase suppressor of Ras 2.	Connector enhancer of kinase suppressor of ras 2.	0.875
FGIG_03075	FGIG_07351	A0A504YY59	A0A504YX93	Kinase suppressor of Ras 2.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide; Belongs to the 14-3-3 family.	0.766
FGIG_03075	FGIG_11567	A0A504YY59	A0A504Y777	Kinase suppressor of Ras 2.	PDZ domain-containing protein.	0.442
FGIG_03075	FGIG_12079	A0A504YY59	A0A504YNS3	Kinase suppressor of Ras 2.	14-3-3 protein zeta/delta; Belongs to the 14-3-3 family.	0.766
FGIG_03075	FGIG_12158	A0A504YY59	A0A504YKF3	Kinase suppressor of Ras 2.	14-3-3 protein epsilon; Belongs to the 14-3-3 family.	0.766
FGIG_03075	FGIG_12213	A0A504YY59	A0A504YHS9	Kinase suppressor of Ras 2.	14-3-3 protein beta/alpha.	0.766
FGIG_03833	FGIG_00155	A0A504YKQ3	A0A504WSS7	Serine/threonine-protein kinase MARK2.	14_3_3 domain-containing protein.	0.699
FGIG_03833	FGIG_01864	A0A504YKQ3	A0A504YSK0	Serine/threonine-protein kinase MARK2.	SH3 and multiple ankyrin repeat domains protein 3.	0.651
FGIG_03833	FGIG_03075	A0A504YKQ3	A0A504YY59	Serine/threonine-protein kinase MARK2.	Kinase suppressor of Ras 2.	0.736
FGIG_03833	FGIG_05814	A0A504YKQ3	A0A504YKJ3	Serine/threonine-protein kinase MARK2.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide; Belongs to the 14-3-3 family.	0.699

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Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.925

expected number of edges:

10

PPI enrichment p-value:

1.66e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030150

Protein import into mitochondrial matrix

8 of 14

3.12

10.27

5.23e-20

GO:0006996

Organelle organization

9 of 1760

1.07

1.29

3.24e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043813

phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

2 of 2

3.36

1.53

0.0018

GO:0008320

Protein transmembrane transporter activity

2 of 11

2.62

1.19

0.0067

GO:0016791

Phosphatase activity

3 of 207

1.52

0.84

0.0174

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005744

TIM23 mitochondrial import inner membrane translocase complex

6 of 7

3.3

8.03

1.85e-15

GO:0098800

Inner mitochondrial membrane protein complex

7 of 85

2.28

5.56

9.18e-13

GO:0005743

Mitochondrial inner membrane

8 of 232

1.9

4.38

2.63e-12

GO:0098796

Membrane protein complex

9 of 635

1.52

2.86

3.11e-11

GO:0001405

PAM complex, Tim23 associated import motor

2 of 2

3.36

2.36

5.57e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8645

TIM23 mitochondrial import inner membrane translocase complex, and Tim44-like domain

7 of 8

3.31

9.38

5.29e-18

CL:13322

Synthesis of PIPs at the late endosome membrane

4 of 5

3.27

4.99

8.09e-10

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1268020

Mitochondrial protein import

7 of 38

2.63

7.03

1.12e-14

MAP-1660517

Synthesis of PIPs at the late endosome membrane

4 of 7

3.12

4.74

2.12e-09

MAP-1660516

Synthesis of PIPs at the early endosome membrane

4 of 11

2.92

4.43

6.58e-09

MAP-1660514

Synthesis of PIPs at the Golgi membrane

4 of 11

2.92

4.43

6.58e-09

MAP-9609507

Protein localization

7 of 152

2.03

4.35

5.40e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005744

TIM23 mitochondrial import inner membrane translocase complex

7 of 9

3.25

9.46

3.21e-18

GOCC:0005743

Mitochondrial inner membrane

8 of 125

2.17

5.76

4.28e-14

GOCC:0001405

PAM complex, Tim23 associated import motor

3 of 3

3.36

3.88

9.61e-08

GOCC:0098796

Membrane protein complex

9 of 479

1.64

3.45

2.53e-12

GOCC:0031090

Organelle membrane

11 of 972

1.42

2.76

8.98e-14

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0496

Mitochondrion

3 of 76

1.96

1.46

0.0013

KW-0811

Translocation

2 of 15

2.49

1.36

0.0032

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02466

Tim17/Tim22/Tim23/Pmp24 family

2 of 4

3.06

1.34

0.0039

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