FGIG_02559 protein (Fasciola gigantica) - STRING interaction network

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second shell of interactors

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filled nodes:
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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

FGIG_02559

26S protease regulatory subunit 7. (76 aa)

Predicted Functional Partners:

FGIG_01066

0.927

FGIG_04527

0.927

FGIG_03693

0.910

FGIG_02557

0.902

FGIG_08057

0.896

FGIG_10496

0.894

FGIG_03983

0.891

FGIG_12102

0.888

FGIG_09948

0.884

FGIG_01358

0.884

Your Current Organism:

Fasciola gigantica

NCBI taxonomy Id: 46835
Other names: F. gigantica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGIG_01066	FGIG_01358	A0A504Y596	A0A504YX21	26S proteasome non-ATPase regulatory subunit 6.	26S proteasome non-ATPase regulatory subunit 4.	0.999
FGIG_01066	FGIG_02557	A0A504Y596	A0A504YPG9	26S proteasome non-ATPase regulatory subunit 6.	Proteasome (Prosome macropain) 26S subunit ATPase 5; Belongs to the AAA ATPase family.	0.999
FGIG_01066	FGIG_02559	A0A504Y596	A0A504YSS5	26S proteasome non-ATPase regulatory subunit 6.	26S protease regulatory subunit 7.	0.927
FGIG_01066	FGIG_03693	A0A504Y596	A0A504YV76	26S proteasome non-ATPase regulatory subunit 6.	Proteasome (Prosome macropain) 26S subunit ATPase 3; Belongs to the AAA ATPase family.	0.999
FGIG_01066	FGIG_03983	A0A504Y596	A0A504WSR5	26S proteasome non-ATPase regulatory subunit 6.	26S proteasome non-ATPase regulatory subunit.	0.999
FGIG_01066	FGIG_04527	A0A504Y596	A0A504Z1X5	26S proteasome non-ATPase regulatory subunit 6.	Proteasome 26S subunit subunit 4 ATPase; Belongs to the AAA ATPase family.	0.999
FGIG_01066	FGIG_08057	A0A504Y596	A0A504YCY0	26S proteasome non-ATPase regulatory subunit 6.	Proteasome (Prosome macropain) 26S subunit ATPase 4; Belongs to the AAA ATPase family.	0.999
FGIG_01066	FGIG_09948	A0A504Y596	A0A504YLZ3	26S proteasome non-ATPase regulatory subunit 6.	26S proteasome non-ATPase regulatory subunit.	0.999
FGIG_01066	FGIG_10496	A0A504Y596	A0A504YW88	26S proteasome non-ATPase regulatory subunit 6.	Proteasome subunit alpha type.	0.999
FGIG_01066	FGIG_12102	A0A504Y596	A0A504Z113	26S proteasome non-ATPase regulatory subunit 6.	26S proteasome non-ATPase regulatory subunit.	0.999
FGIG_01358	FGIG_01066	A0A504YX21	A0A504Y596	26S proteasome non-ATPase regulatory subunit 4.	26S proteasome non-ATPase regulatory subunit 6.	0.999
FGIG_01358	FGIG_02557	A0A504YX21	A0A504YPG9	26S proteasome non-ATPase regulatory subunit 4.	Proteasome (Prosome macropain) 26S subunit ATPase 5; Belongs to the AAA ATPase family.	0.999
FGIG_01358	FGIG_02559	A0A504YX21	A0A504YSS5	26S proteasome non-ATPase regulatory subunit 4.	26S protease regulatory subunit 7.	0.884
FGIG_01358	FGIG_03693	A0A504YX21	A0A504YV76	26S proteasome non-ATPase regulatory subunit 4.	Proteasome (Prosome macropain) 26S subunit ATPase 3; Belongs to the AAA ATPase family.	0.999
FGIG_01358	FGIG_03983	A0A504YX21	A0A504WSR5	26S proteasome non-ATPase regulatory subunit 4.	26S proteasome non-ATPase regulatory subunit.	0.999
FGIG_01358	FGIG_04527	A0A504YX21	A0A504Z1X5	26S proteasome non-ATPase regulatory subunit 4.	Proteasome 26S subunit subunit 4 ATPase; Belongs to the AAA ATPase family.	0.999
FGIG_01358	FGIG_08057	A0A504YX21	A0A504YCY0	26S proteasome non-ATPase regulatory subunit 4.	Proteasome (Prosome macropain) 26S subunit ATPase 4; Belongs to the AAA ATPase family.	0.999
FGIG_01358	FGIG_09948	A0A504YX21	A0A504YLZ3	26S proteasome non-ATPase regulatory subunit 4.	26S proteasome non-ATPase regulatory subunit.	0.999
FGIG_01358	FGIG_10496	A0A504YX21	A0A504YW88	26S proteasome non-ATPase regulatory subunit 4.	Proteasome subunit alpha type.	0.998
FGIG_01358	FGIG_12102	A0A504YX21	A0A504Z113	26S proteasome non-ATPase regulatory subunit 4.	26S proteasome non-ATPase regulatory subunit.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.933

expected number of edges:

10

PPI enrichment p-value:

1.88e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006665

Sphingolipid metabolic process

7 of 109

2.33

6.08

1.14e-12

GO:0030148

Sphingolipid biosynthetic process

6 of 57

2.55

6.05

1.11e-11

GO:0046512

Sphingosine biosynthetic process

4 of 9

3.17

5.23

2.31e-09

GO:0006672

Ceramide metabolic process

5 of 50

2.52

4.89

2.01e-09

GO:0030149

Sphingolipid catabolic process

4 of 43

2.49

3.78

2.46e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001727

Lipid kinase activity

3 of 4

3.4

3.58

1.47e-06

GO:0017040

N-acylsphingosine amidohydrolase activity

3 of 9

3.05

3.24

4.62e-06

GO:0003951

NAD+ kinase activity

3 of 19

2.72

2.79

2.16e-05

GO:0071633

Dihydroceramidase activity

2 of 2

3.52

2.19

0.00028

GO:0102121

Ceramidase activity

2 of 6

3.05

1.84

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:34972

Sphingolipid metabolism

6 of 50

2.6

6.19

8.49e-12

CL:34973

Sphingolipid metabolism

5 of 37

2.65

5.39

3.95e-10

CL:34974

Sphingolipid metabolism

4 of 31

2.63

4.01

1.35e-07

CL:34977

Ceramide biosynthetic process, and N-acylsphingosine amidohydrolase activity

3 of 16

2.8

2.97

1.15e-05

CL:34999

N-acylsphingosine amidohydrolase activity, and Ceramide kinase activity

2 of 5

3.13

1.88

0.00086

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lak00600

Sphingolipid metabolism

5 of 77

2.34

4.69

1.70e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-428157

Sphingolipid metabolism

7 of 142

2.22

5.72

1.56e-12

MAP-1660662

Glycosphingolipid metabolism

4 of 107

2.1

2.71

8.72e-06

MAP-1660661

Sphingolipid de novo biosynthesis

3 of 35

2.46

2.52

4.95e-05

MAP-556833

Metabolism of lipids

7 of 1070

1.34

1.8

8.82e-07

MAP-1430728

Metabolism

7 of 3499

0.82

0.67

0.0013

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030173

Integral component of Golgi membrane

2 of 20

2.52

0.99

0.0236

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05875

Ceramidase

2 of 2

3.52

1.83

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001206

Diacylglycerol kinase, catalytic domain

3 of 11

2.96

2.65

4.34e-05

IPR017438

Inorganic polyphosphate/ATP-NAD kinase, N-terminal

3 of 13

2.89

2.64

4.34e-05

IPR016064

NAD kinase/diacylglycerol kinase-like domain superfamily

3 of 13

2.89

2.64

4.34e-05

IPR045363

Ceramide kinase, C-terminal domain

2 of 2

3.52

1.91

0.00080

IPR008901

Alkaline ceramidase

2 of 2

3.52

1.91

0.00080

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00046

Diacylglycerol kinase catalytic domain (presumed)

2 of 10

2.82

1.49

0.0037

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