FGIG_01875 protein (Fasciola gigantica) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

FGIG_01875

Uncharacterized protein. (244 aa)

Predicted Functional Partners:

FGIG_10835

0.923

FGIG_04123

0.711

FGIG_11990

0.657

FGIG_08484

0.588

FGIG_08485

0.588

FGIG_05065

0.577

FGIG_02799

0.528

FGIG_05297

0.515

FGIG_00800

0.506

FGIG_11898

0.426

Your Current Organism:

Fasciola gigantica

NCBI taxonomy Id: 46835
Other names: F. gigantica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGIG_00800	FGIG_01875	A0A504YR27	A0A504Z0S4	Nuclear protein localization 4.	Uncharacterized protein.	0.506
FGIG_00800	FGIG_02799	A0A504YR27	A0A504Z4T1	Nuclear protein localization 4.	Ankyrin repeat and zinc finger domain-containing protein 1.	0.655
FGIG_00800	FGIG_04123	A0A504YR27	A0A504Y6N7	Nuclear protein localization 4.	E3 ubiquitin-protein ligase listerin.	0.603
FGIG_00800	FGIG_05065	A0A504YR27	A0A504YP58	Nuclear protein localization 4.	AAA family ATPase.	0.957
FGIG_00800	FGIG_05297	A0A504YR27	A0A504YVW3	Nuclear protein localization 4.	Ubiquitin fusion degradation protein 1.	0.999
FGIG_00800	FGIG_08484	A0A504YR27	A0A504YME5	Nuclear protein localization 4.	Nuclear export mediator factor NEMF.	0.573
FGIG_00800	FGIG_08485	A0A504YR27	A0A504YU15	Nuclear protein localization 4.	Nuclear export mediator factor NEMF.	0.573
FGIG_00800	FGIG_10835	A0A504YR27	A0A504YIW3	Nuclear protein localization 4.	Uncharacterized protein.	0.506
FGIG_00800	FGIG_11990	A0A504YR27	A0A504YJX6	Nuclear protein localization 4.	Transitional endoplasmic reticulum ATPase TER94; Belongs to the AAA ATPase family.	0.999
FGIG_01875	FGIG_00800	A0A504Z0S4	A0A504YR27	Uncharacterized protein.	Nuclear protein localization 4.	0.506
FGIG_01875	FGIG_02799	A0A504Z0S4	A0A504Z4T1	Uncharacterized protein.	Ankyrin repeat and zinc finger domain-containing protein 1.	0.528
FGIG_01875	FGIG_04123	A0A504Z0S4	A0A504Y6N7	Uncharacterized protein.	E3 ubiquitin-protein ligase listerin.	0.711
FGIG_01875	FGIG_05065	A0A504Z0S4	A0A504YP58	Uncharacterized protein.	AAA family ATPase.	0.577
FGIG_01875	FGIG_05297	A0A504Z0S4	A0A504YVW3	Uncharacterized protein.	Ubiquitin fusion degradation protein 1.	0.515
FGIG_01875	FGIG_08484	A0A504Z0S4	A0A504YME5	Uncharacterized protein.	Nuclear export mediator factor NEMF.	0.588
FGIG_01875	FGIG_08485	A0A504Z0S4	A0A504YU15	Uncharacterized protein.	Nuclear export mediator factor NEMF.	0.588
FGIG_01875	FGIG_10835	A0A504Z0S4	A0A504YIW3	Uncharacterized protein.	Uncharacterized protein.	0.923
FGIG_01875	FGIG_11898	A0A504Z0S4	A0A504YM24	Uncharacterized protein.	Zinc finger protein.	0.426
FGIG_01875	FGIG_11990	A0A504Z0S4	A0A504YJX6	Uncharacterized protein.	Transitional endoplasmic reticulum ATPase TER94; Belongs to the AAA ATPase family.	0.657
FGIG_02799	FGIG_00800	A0A504Z4T1	A0A504YR27	Ankyrin repeat and zinc finger domain-containing protein 1.	Nuclear protein localization 4.	0.655

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.86

expected number of edges:

23

PPI enrichment p-value:

0.24

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

4 of 12

2.99

3.94

5.84e-08

GO:0031204

Post-translational protein targeting to membrane, translocation

4 of 13

2.95

3.93

5.84e-08

GO:0071423

Malate transmembrane transport

2 of 14

2.62

1.4

0.0028

GO:0006817

Phosphate ion transport

2 of 47

2.09

0.89

0.0215

GO:0071702

Organic substance transport

6 of 1713

1.01

0.81

0.0020

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005048

Signal sequence binding

4 of 35

2.52

3.11

1.29e-06

GO:0008320

Protein transmembrane transporter activity

4 of 53

2.34

2.84

3.08e-06

GO:0043022

Ribosome binding

4 of 59

2.3

2.82

3.08e-06

GO:0015117

Thiosulfate transmembrane transporter activity

2 of 8

2.86

1.65

0.0010

GO:0015141

Succinate transmembrane transporter activity

2 of 10

2.77

1.59

0.0013

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005784

Sec61 translocon complex

4 of 9

3.11

4.57

4.36e-09

GO:0031967

Organelle envelope

8 of 1591

1.17

1.44

8.78e-07

GO:0031966

Mitochondrial membrane

4 of 483

1.38

1.17

0.0012

GO:0009535

Chloroplast thylakoid membrane

4 of 499

1.37

1.16

0.0012

GO:0031225

Anchored component of membrane

3 of 284

1.49

1.07

0.0038

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:41198

Mixed, incl. Malate transmembrane transport, and Unstructured region between BRX_N and BRX domain

4 of 15

2.89

3.7

1.51e-07

CL:41200

Mixed, incl. Malate transmembrane transport, and Peptidase S8, subtilisin, Asp-active site

3 of 10

2.94

2.71

1.12e-05

CL:7441

Mixed, incl. Copper chaperone SCO1/SenC, and Cytochrome c, class IA/ IB

3 of 16

2.74

2.46

3.03e-05

CL:41205

Mixed, incl. Thiosulfate transport, and Transcription factor LHW-like

2 of 5

3.07

1.6

0.0013

CL:3325

Post-translational protein targeting to membrane, translocation, and Protein translocase SEC61 complex, gamma subunit

2 of 17

2.54

1.1

0.0096

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03060

Protein export

4 of 89

2.12

2.7

3.21e-06

map04145

Phagosome

4 of 204

1.76

1.96

4.08e-05

map04141

Protein processing in endoplasmic reticulum

4 of 505

1.36

1.18

0.00094

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236974

ER-Phagosome pathway

4 of 4

3.47

5.17

4.43e-10

MAP-9707564

Cytoprotection by HMOX1

4 of 74

2.2

2.69

4.46e-06

MAP-1236975

Antigen processing-Cross presentation

4 of 120

1.99

2.27

1.94e-05

MAP-5628897

TP53 Regulates Metabolic Genes

4 of 159

1.87

2.04

4.36e-05

MAP-611105

Respiratory electron transport

4 of 189

1.79

1.9

6.86e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005784

Sec61 translocon complex

4 of 9

3.11

4.45

7.16e-09

GOCC:0098588

Bounding membrane of organelle

5 of 862

1.23

1.05

0.0011

GOCC:0005739

Mitochondrion

4 of 1095

1.03

0.54

0.0416

GOCC:0016020

Membrane

7 of 4235

0.68

0.44

0.0211

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00344

SecY

4 of 6

3.29

4.67

3.30e-09

PF10559

Plug domain of Sec61p

3 of 3

3.47

3.44

6.30e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023201

SecY domain superfamily

4 of 6

3.29

4.41

9.75e-09

IPR002208

SecY/SEC61-alpha family

4 of 6

3.29

4.41

9.75e-09

IPR019561

Translocon Sec61/SecY, plug domain

3 of 3

3.47

3.27

1.24e-06

IPR030659

SecY conserved site

3 of 4

3.34

3.2

1.63e-06

IPR043325

Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein

3 of 23

2.58

2.17

9.66e-05

(more ...)

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