STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FGIG_0675326S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (974 aa)    
Predicted Functional Partners:
FGIG_03983
26S proteasome non-ATPase regulatory subunit.
   
 0.999
FGIG_01066
26S proteasome non-ATPase regulatory subunit 6.
   
 0.999
FGIG_00637
26S proteasome non ATPase regulatory subunit.
   
 0.999
FGIG_02557
Proteasome (Prosome macropain) 26S subunit ATPase 5; Belongs to the AAA ATPase family.
   
 0.999
FGIG_03693
Proteasome (Prosome macropain) 26S subunit ATPase 3; Belongs to the AAA ATPase family.
   
 0.999
FGIG_12102
26S proteasome non-ATPase regulatory subunit.
   
 0.999
FGIG_04527
Proteasome 26S subunit subunit 4 ATPase; Belongs to the AAA ATPase family.
   
 0.999
FGIG_02925
26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.
   
0.999
FGIG_08057
Proteasome (Prosome macropain) 26S subunit ATPase 4; Belongs to the AAA ATPase family.
   
 0.998
FGIG_09948
26S proteasome non-ATPase regulatory subunit.
   
 0.998
Your Current Organism:
Fasciola gigantica
NCBI taxonomy Id: 46835
Other names: F. gigantica
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.