STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FGIG_01378DNA repair endonuclease XPF. (719 aa)    
Predicted Functional Partners:
FGIG_10253
DNA excision repair protein ERCC-1.
   
 0.987
FGIG_09810
DNA-repair protein complementing XP-A cell.
    
 0.981
FGIG_01377
DNA repair endonuclease XPF.
 
     0.942
FGIG_04012
Crossover junction endonuclease MUS81.
    
 0.924
FGIG_07428
DNA repair protein complementing XP-G cell.
   
 0.909
FGIG_08854
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
    
 0.893
FGIG_01643
Bloom syndrome protein.
    
 0.889
FGIG_11273
Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.
    
 0.877
FGIG_01401
Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.
   
 0.871
FGIG_09676
ATP-dependent DNA helicase Q4.
    
 0.862
Your Current Organism:
Fasciola gigantica
NCBI taxonomy Id: 46835
Other names: F. gigantica
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.