Tbis_2089 protein (Thermobispora bispora) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

Tbis_2089

PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: bpt:Bpet0262 hypothetical protein; Belongs to the CoA-transferase III family. (363 aa)

Predicted Functional Partners:

argH

0.589

Tbis_2092

0.453

Tbis_0516

0.452

Tbis_2090

0.420

Your Current Organism:

Thermobispora bispora

NCBI taxonomy Id: 469371
Other names: T. bispora DSM 43833, Thermobispora bispora ATCC 19993, Thermobispora bispora DSM 43833, Thermobispora bispora str. DSM 43833, Thermobispora bispora strain DSM 43833

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Tbis_0516	Tbis_2089	Tbis_0516	Tbis_2089	PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: pna:Pnap_0798 short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: bpt:Bpet0262 hypothetical protein; Belongs to the CoA-transferase III family.	0.452
Tbis_2089	Tbis_0516	Tbis_2089	Tbis_0516	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: bpt:Bpet0262 hypothetical protein; Belongs to the CoA-transferase III family.	PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: pna:Pnap_0798 short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.452
Tbis_2089	Tbis_2090	Tbis_2089	Tbis_2090	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: bpt:Bpet0262 hypothetical protein; Belongs to the CoA-transferase III family.	PFAM: Enoyl-CoA hydratase/isomerase; KEGG: nar:Saro_1417 enoyl-CoA hydratase.	0.420
Tbis_2089	Tbis_2092	Tbis_2089	Tbis_2092	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: bpt:Bpet0262 hypothetical protein; Belongs to the CoA-transferase III family.	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: dsh:Dshi_2494 acyl-CoA transferase/carnitine dehydratase-like protein; Belongs to the CoA-transferase III family.	0.453
Tbis_2089	argH	Tbis_2089	Tbis_2024	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: bpt:Bpet0262 hypothetical protein; Belongs to the CoA-transferase III family.	TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: bac:BamMC406_6164 argininosuccinate lyase.	0.589
Tbis_2090	Tbis_2089	Tbis_2090	Tbis_2089	PFAM: Enoyl-CoA hydratase/isomerase; KEGG: nar:Saro_1417 enoyl-CoA hydratase.	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: bpt:Bpet0262 hypothetical protein; Belongs to the CoA-transferase III family.	0.420
Tbis_2090	Tbis_2092	Tbis_2090	Tbis_2092	PFAM: Enoyl-CoA hydratase/isomerase; KEGG: nar:Saro_1417 enoyl-CoA hydratase.	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: dsh:Dshi_2494 acyl-CoA transferase/carnitine dehydratase-like protein; Belongs to the CoA-transferase III family.	0.414
Tbis_2092	Tbis_2089	Tbis_2092	Tbis_2089	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: dsh:Dshi_2494 acyl-CoA transferase/carnitine dehydratase-like protein; Belongs to the CoA-transferase III family.	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: bpt:Bpet0262 hypothetical protein; Belongs to the CoA-transferase III family.	0.453
Tbis_2092	Tbis_2090	Tbis_2092	Tbis_2090	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: dsh:Dshi_2494 acyl-CoA transferase/carnitine dehydratase-like protein; Belongs to the CoA-transferase III family.	PFAM: Enoyl-CoA hydratase/isomerase; KEGG: nar:Saro_1417 enoyl-CoA hydratase.	0.414
argH	Tbis_2089	Tbis_2024	Tbis_2089	TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: bac:BamMC406_6164 argininosuccinate lyase.	PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: bpt:Bpet0262 hypothetical protein; Belongs to the CoA-transferase III family.	0.589

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.88

expected number of edges:

12

PPI enrichment p-value:

7.14e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

4 of 30

2.15

2.12

6.84e-05

GO:0006097

Glyoxylate cycle

2 of 2

3.03

1.41

0.0029

GO:0005975

Carbohydrate metabolic process

6 of 447

1.16

0.96

0.0014

GO:0006094

Gluconeogenesis

2 of 12

2.25

0.84

0.0289

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046912

Acyltransferase activity, acyl groups converted into alkyl on transfer

3 of 13

2.39

1.75

0.00054

GO:0042132

Fructose 1,6-bisphosphate 1-phosphatase activity

2 of 2

3.03

1.34

0.0038

GO:0004108

Citrate (Si)-synthase activity

2 of 2

3.03

1.34

0.0038

GO:0016746

Acyltransferase activity

4 of 188

1.36

0.95

0.0055

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009514

Glyoxysome

2 of 2

3.03

1.33

0.0039

GO:0042597

Periplasmic space

2 of 4

2.73

1.27

0.0049

GO:0005777

Peroxisome

3 of 82

1.59

0.93

0.0118

GO:0005737

Cytoplasm

11 of 4517

0.42

0.32

0.0074

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9454

Citrate synthase, and Citrate metabolic process

2 of 5

2.63

0.82

0.0323

CL:17099

Mixed, incl. Sequestering of actin monomers, and C4-dicarboxylate transmembrane transporter activity

2 of 5

2.63

0.82

0.0323

CL:11084

Glyoxysome, and Isocitrate lyase

2 of 5

2.63

0.82

0.0323

CL:10111

Glycolytic process, and Insulin effects increased synthesis of Xylulose-5-Phosphate

2 of 18

2.07

0.74

0.0415

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

plj01200

Carbon metabolism

6 of 113

1.75

2.86

5.15e-08

plj00630

Glyoxylate and dicarboxylate metabolism

4 of 36

2.07

2.72

2.29e-06

plj00020

Citrate cycle (TCA cycle)

2 of 28

1.88

1.06

0.0084

plj01210

2-Oxocarboxylic acid metabolism

2 of 32

1.82

1.04

0.0090

plj01110

Biosynthesis of secondary metabolites

5 of 415

1.11

0.96

0.00090

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009514

Glyoxysome

2 of 3

2.85

1.17

0.0078

GOCC:0042597

Periplasmic space

2 of 13

2.22

0.76

0.0406

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00316

Fructose-1-6-bisphosphatase, N-terminal domain

2 of 2

3.03

1.28

0.0050

PF00285

Citrate synthase, C-terminal domain

2 of 3

2.85

1.27

0.0050

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044015

Fructose-1-6-bisphosphatase class 1, C-terminal

2 of 2

3.03

1.03

0.0141

IPR033391

Fructose-1-6-bisphosphatase class I, N-terminal

2 of 2

3.03

1.03

0.0141

IPR020548

Fructose-1,6-bisphosphatase, active site

2 of 2

3.03

1.03

0.0141

IPR019810

Citrate synthase active site

2 of 2

3.03

1.03

0.0141

IPR000146

Fructose-1,6-bisphosphatase class 1

2 of 2

3.03

1.03

0.0141

(more ...)

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