STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cwoe_5210PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: scl:sce8127 putative acetolactate synthase; Belongs to the TPP enzyme family. (549 aa)    
Predicted Functional Partners:
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.976
Cwoe_0206
KEGG: mca:MCA1838 alpha-acetolactate decarboxylase; TIGRFAM: alpha-acetolactate decarboxylase; PFAM: alpha-acetolactate decarboxylase.
  
 
 0.954
Cwoe_1031
Tartrate decarboxylase; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rle:pRL110153 putative tartrate dehydrogenase.
 
 0.935
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.935
Cwoe_4230
TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; amino acid-binding ACT domain protein; KEGG: glo:Glov_0480 threonine dehydratase.
  
 0.932
Cwoe_4712
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: afw:Anae109_1891 pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein.
  
 
 0.922
Cwoe_4711
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: afw:Anae109_1892 2-oxoglutarate ferredoxin oxidoreductase subunit beta.
  
 
 0.912
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.905
Cwoe_2184
PFAM: HpcH/HpaI aldolase; KEGG: ypy:YPK_2266 HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family.
    
  0.901
Cwoe_3579
TIGRFAM: acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein; KEGG: sfu:Sfum_3022 acetolactate synthase, small subunit.
 
 0.889
Your Current Organism:
Conexibacter woesei DSM 14684
NCBI taxonomy Id: 469383
Other names: C. woesei DSM 14684, Conexibacter woesei str. DSM 14684, Conexibacter woesei strain DSM 14684
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.