node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFL83287.1 | EFL83526.1 | HMPREF0189_00364 | HMPREF0189_00604 | HAD hydrolase, family IB. | Aspartate kinase, monofunctional class; Belongs to the aspartokinase family. | 0.614 |
EFL83287.1 | folK | HMPREF0189_00364 | HMPREF0189_00366 | HAD hydrolase, family IB. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | 0.622 |
EFL83287.1 | hda | HMPREF0189_00364 | HMPREF0189_00363 | HAD hydrolase, family IB. | DnaA regulatory inactivator Hda; Belongs to the DnaA family. | 0.791 |
EFL83287.1 | hisF | HMPREF0189_00364 | HMPREF0189_00186 | HAD hydrolase, family IB. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.659 |
EFL83287.1 | hisZ | HMPREF0189_00364 | HMPREF0189_01143 | HAD hydrolase, family IB. | Putative ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.651 |
EFL83287.1 | panB | HMPREF0189_00364 | HMPREF0189_00367 | HAD hydrolase, family IB. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.619 |
EFL83287.1 | panC | HMPREF0189_00364 | HMPREF0189_00368 | HAD hydrolase, family IB. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.608 |
EFL83287.1 | pcnB | HMPREF0189_00364 | HMPREF0189_00365 | HAD hydrolase, family IB. | Putative polynucleotide adenylyltransferase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.687 |
EFL83287.1 | pgpA | HMPREF0189_00364 | HMPREF0189_02088 | HAD hydrolase, family IB. | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). | 0.663 |
EFL83287.1 | pgsA | HMPREF0189_00364 | HMPREF0189_02299 | HAD hydrolase, family IB. | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.631 |
EFL83526.1 | EFL83287.1 | HMPREF0189_00604 | HMPREF0189_00364 | Aspartate kinase, monofunctional class; Belongs to the aspartokinase family. | HAD hydrolase, family IB. | 0.614 |
EFL83526.1 | hisF | HMPREF0189_00604 | HMPREF0189_00186 | Aspartate kinase, monofunctional class; Belongs to the aspartokinase family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.487 |
folK | EFL83287.1 | HMPREF0189_00366 | HMPREF0189_00364 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | HAD hydrolase, family IB. | 0.622 |
folK | hda | HMPREF0189_00366 | HMPREF0189_00363 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | DnaA regulatory inactivator Hda; Belongs to the DnaA family. | 0.629 |
folK | panB | HMPREF0189_00366 | HMPREF0189_00367 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.880 |
folK | panC | HMPREF0189_00366 | HMPREF0189_00368 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.811 |
folK | pcnB | HMPREF0189_00366 | HMPREF0189_00365 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | Putative polynucleotide adenylyltransferase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.945 |
hda | EFL83287.1 | HMPREF0189_00363 | HMPREF0189_00364 | DnaA regulatory inactivator Hda; Belongs to the DnaA family. | HAD hydrolase, family IB. | 0.791 |
hda | folK | HMPREF0189_00363 | HMPREF0189_00366 | DnaA regulatory inactivator Hda; Belongs to the DnaA family. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase. | 0.629 |
hda | panB | HMPREF0189_00363 | HMPREF0189_00367 | DnaA regulatory inactivator Hda; Belongs to the DnaA family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.634 |