node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cyaY | fdx | HMPREF0189_00130 | HMPREF0189_01046 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Ferredoxin, 2Fe-2S type, ISC system. | 0.948 |
cyaY | hscA | HMPREF0189_00130 | HMPREF0189_01045 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.576 |
cyaY | hscB | HMPREF0189_00130 | HMPREF0189_01044 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.822 |
cyaY | iscA | HMPREF0189_00130 | HMPREF0189_01043 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Iron-sulfur cluster assembly protein IscA; Belongs to the HesB/IscA family. | 0.400 |
cyaY | iscS | HMPREF0189_00130 | HMPREF0189_01041 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.999 |
cyaY | iscU | HMPREF0189_00130 | HMPREF0189_01042 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.999 |
cyaY | iscX | HMPREF0189_00130 | HMPREF0189_01047 | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | FeS assembly protein IscX. | 0.786 |
dnaK | fdx | HMPREF0189_00261 | HMPREF0189_01046 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Ferredoxin, 2Fe-2S type, ISC system. | 0.542 |
dnaK | hscB | HMPREF0189_00261 | HMPREF0189_01044 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.875 |
dnaK | iscA | HMPREF0189_00261 | HMPREF0189_01043 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Iron-sulfur cluster assembly protein IscA; Belongs to the HesB/IscA family. | 0.521 |
dnaK | iscS | HMPREF0189_00261 | HMPREF0189_01041 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.497 |
dnaK | iscU | HMPREF0189_00261 | HMPREF0189_01042 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.884 |
erpA | hscB | HMPREF0189_02101 | HMPREF0189_01044 | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.746 |
erpA | iscS | HMPREF0189_02101 | HMPREF0189_01041 | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.648 |
erpA | iscU | HMPREF0189_02101 | HMPREF0189_01042 | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.803 |
fdx | cyaY | HMPREF0189_01046 | HMPREF0189_00130 | Ferredoxin, 2Fe-2S type, ISC system. | Iron donor protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.948 |
fdx | dnaK | HMPREF0189_01046 | HMPREF0189_00261 | Ferredoxin, 2Fe-2S type, ISC system. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.542 |
fdx | hscA | HMPREF0189_01046 | HMPREF0189_01045 | Ferredoxin, 2Fe-2S type, ISC system. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.959 |
fdx | hscB | HMPREF0189_01046 | HMPREF0189_01044 | Ferredoxin, 2Fe-2S type, ISC system. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.993 |
fdx | iscA | HMPREF0189_01046 | HMPREF0189_01043 | Ferredoxin, 2Fe-2S type, ISC system. | Iron-sulfur cluster assembly protein IscA; Belongs to the HesB/IscA family. | 0.969 |