nadK protein (Fusobacterium varium) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

nadK

NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (201 aa)

Predicted Functional Partners:

nadD

0.950

nadE

0.945

EES63036.1

0.926

mazG

0.900

recN

0.860

era

0.814

EES64577.1

0.813

rrmJ

0.597

EES64574.1

0.552

ffh

0.548

Your Current Organism:

Fusobacterium varium

NCBI taxonomy Id: 469618
Other names: F. varium ATCC 27725, Fusobacterium varium ATCC 27725

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EES63036.1	mazG	FVAG_00725	FVAG_02447	Putative NAD-dependent deacetylase.	Protein MazG.	0.901
EES63036.1	nadD	FVAG_00725	FVAG_01635	Putative NAD-dependent deacetylase.	Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	0.932
EES63036.1	nadE	FVAG_00725	FVAG_00036	Putative NAD-dependent deacetylase.	NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.	0.928
EES63036.1	nadK	FVAG_00725	FVAG_01258	Putative NAD-dependent deacetylase.	NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.926
EES64574.1	EES64577.1	FVAG_01257	FVAG_01260	Peptidase, M23 family.	Phage integrase SAM-like domain protein; Belongs to the 'phage' integrase family.	0.527
EES64574.1	era	FVAG_01257	FVAG_01261	Peptidase, M23 family.	Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	0.489
EES64574.1	nadK	FVAG_01257	FVAG_01258	Peptidase, M23 family.	NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.552
EES64574.1	recN	FVAG_01257	FVAG_01259	Peptidase, M23 family.	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	0.678
EES64577.1	EES64574.1	FVAG_01260	FVAG_01257	Phage integrase SAM-like domain protein; Belongs to the 'phage' integrase family.	Peptidase, M23 family.	0.527
EES64577.1	era	FVAG_01260	FVAG_01261	Phage integrase SAM-like domain protein; Belongs to the 'phage' integrase family.	Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	0.802
EES64577.1	nadK	FVAG_01260	FVAG_01258	Phage integrase SAM-like domain protein; Belongs to the 'phage' integrase family.	NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.813
EES64577.1	recN	FVAG_01260	FVAG_01259	Phage integrase SAM-like domain protein; Belongs to the 'phage' integrase family.	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	0.857
era	EES64574.1	FVAG_01261	FVAG_01257	Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	Peptidase, M23 family.	0.489
era	EES64577.1	FVAG_01261	FVAG_01260	Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	Phage integrase SAM-like domain protein; Belongs to the 'phage' integrase family.	0.802
era	ffh	FVAG_01261	FVAG_01558	Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.	0.551
era	mazG	FVAG_01261	FVAG_02447	Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	Protein MazG.	0.496
era	nadK	FVAG_01261	FVAG_01258	Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.814
era	recN	FVAG_01261	FVAG_01259	Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	0.830
era	rrmJ	FVAG_01261	FVAG_00032	Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	Ribosomal RNA large subunit methyltransferase J.	0.420
ffh	era	FVAG_01558	FVAG_01261	Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.	Ribosome biogenesis GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.	0.551

page 1 of 3

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Co-occurrence

Databases

Co-expression

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About