STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdkThymidine kinase; KEGG: bfr:BF0659 1.7e-74 thymidine kinase K00857; COG: COG1435 Thymidine kinase; Psort location: Cytoplasmic, score: 8.96. (179 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.967
EDV00429.1
KEGG: bfr:BF1494 6.7e-55 cytidine deaminase K01489; COG: COG0295 Cytidine deaminase.
 
  
 0.958
dut
dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
   
 
 0.951
EDV00103.1
Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: bth:BT4260 4.3e-60 deoxycytidylate deaminase K01493; COG: COG2131 Deoxycytidylate deaminase; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.904
EDV00437.1
KEGG: sil:SPO2904 2.6e-29 Ser/Thr protein phosphatase/nucleotidase, putative K01081; COG: COG0737 5-nucleotidase/2,3-cyclic phosphodiesterase and related esterases.
 
  
  0.903
surE
5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
  
  
  0.888
EDV01780.1
Phosphorylase family; KEGG: bth:BT4554 1.1e-134 purine nucleoside phosphorylase II K00757; COG: COG2820 Uridine phosphorylase; Psort location: Cytoplasmic, score: 8.96.
     
 0.886
EDV02408.1
Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
  0.881
EDU99278.1
KEGG: aha:AHA_0675 2.5e-11 thyA; thymidylate synthase K00560; COG: COG0207 Thymidylate synthase; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.812
prfA
Putative peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.760
Your Current Organism:
Bacteroides coprocola
NCBI taxonomy Id: 470145
Other names: B. coprocola DSM 17136, Bacteroides coprocola DSM 17136, Bacteroides coprocola M16, Bacteroides coprocola str. DSM 17136, Bacteroides coprocola strain DSM 17136
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