STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tcur_0296PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; KEGG: sml:Smlt3523 putative valine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (362 aa)    
Predicted Functional Partners:
Tcur_2866
PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; KEGG: afw:Anae109_0854 glutamate synthase (ferredoxin).
  
 
 0.995
Tcur_4252
TIGRFAM: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase/GMP reductase; KEGG: hso:HS_0420 inosine 5'-monophosphate dehydrogenase.
  
 
 0.926
Tcur_2046
PFAM: aminotransferase class IV; KEGG: hch:HCH_06836 branched-chain amino acid aminotransferase.
  
 
 0.917
Tcur_3543
TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV; KEGG: rhi:NGR_c35490 branched-chain-amino-acid aminotransferase.
  
 
 0.917
Tcur_1565
PFAM: aminotransferase class I and II; KEGG: pau:PA14_27500 aminotransferase AlaT.
  
 
 0.909
Tcur_4210
KEGG: azc:AZC_1865 isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
   
 0.734
cobB-2
Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily.
   
 0.676
Tcur_2245
PFAM: Silent information regulator protein Sir2; KEGG: sat:SYN_00042 sir2 family protein.
   
 0.676
Tcur_3675
TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; catalytic domain of components of various dehydrogenase complexes; KEGG: gsu:GSU2449 alpha-ketoglutarate decarboxylase.
  
 
 0.653
Tcur_0295
Hypothetical protein.
       0.595
Your Current Organism:
Thermomonospora curvata
NCBI taxonomy Id: 471852
Other names: T. curvata DSM 43183, Thermomonospora curvata DSM 43183, Thermomonospora curvata IFO 15933, Thermomonospora curvata JCM 3096, Thermomonospora curvata NBRC 15933, Thermomonospora curvata str. DSM 43183, Thermomonospora curvata strain DSM 43183
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