STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
esxAHypothetical protein; May help regulate assembly and function of the type VII secretion system (T7SS). EsxA disassembles pre-formed EccC-EsxB multimers, possibly by making EccC-EsxA-EsxB trimers instead of EccC-EsxB-EsxB-EccC tetramers. (97 aa)    
Predicted Functional Partners:
esxB
Protein of unknown function DUF909; May help regulate assembly and function of the type VII secretion system (T7SS). Binds to EccC and induces its multimerization. May serve as a chaperone for EsxA (By similarity).
  
 
 0.999
Tcur_0609
PFAM: protein of unknown function DUF690.
 
 
 0.894
Tcur_0608
TIGRFAM: secretion protein snm4; PFAM: protein of unknown function DUF571; KEGG: hypothetical protein.
 
   
 0.871
Tcur_0613
Hypothetical protein; KEGG: GF12424 gene product from transcript GF12424- RA.
 
 
 0.871
eccC
Cell divisionFtsK/SpoIIIE; Part of the ESX specialized secretion system, which exports proteins from the cell including EsxA (ESAT-6) and EsxB (CFP-10). Has weak intrinsic ATPase activity; probably only the first FtsK domain can hydrolyze ATP. Might be the translocase subunit.
 
 
 
 0.828
Tcur_0616
KEGG: hypothetical protein; Belongs to the WXG100 family.
 
 
 0.810
Tcur_0614
PFAM: peptidase S8 and S53 subtilisin kexin sedolisin; KEGG: hypothetical protein.
 
   
 0.565
Tcur_0623
ATPase involved in chromosome partitioning-like protein; KEGG: hypothetical protein.
 
 
 
 0.564
Tcur_3308
PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: dal:Dalk_3204 cell divisionFtsK/SpoIIIE.
   
 
 0.557
Tcur_4147
PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase; KEGG: asa:ASA_2438 DNA translocase FtsK.
   
 
 0.550
Your Current Organism:
Thermomonospora curvata
NCBI taxonomy Id: 471852
Other names: T. curvata DSM 43183, Thermomonospora curvata DSM 43183, Thermomonospora curvata IFO 15933, Thermomonospora curvata JCM 3096, Thermomonospora curvata NBRC 15933, Thermomonospora curvata str. DSM 43183, Thermomonospora curvata strain DSM 43183
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