STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tcur_0892PFAM: inositol monophosphatase; KEGG: dvm:DvMF_0345 inositol-phosphate phosphatase. (272 aa)    
Predicted Functional Partners:
Tcur_4958
TIGRFAM: inositol 1-phosphate synthase; PFAM: Myo-inositol-1-phosphate synthase; Myo- inositol-1-phosphate synthase GAPDH domain protein; KEGG: sme:SM_b20249 putative myo-inositol-1- phosphate synthase.
  
 
 0.967
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.934
Tcur_2018
PFAM: inositol monophosphatase; KEGG: shm:Shewmr7_1815 inositol-phosphate phosphatase.
  
  
0.929
Tcur_1692
PFAM: inositol monophosphatase; KEGG: msu:MS1729 SuhB protein.
  
  
0.927
hisA
Bifunctional HisA/TrpF protein; KEGG: plu:plu0797 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase; TIGRFAM: bifunctional HisA/TrpF protein; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein.
  
  
 0.913
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.803
Tcur_0893
Hypothetical protein.
       0.802
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
  
 0.781
hisB
PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mno:Mnod_7533 imidazoleglycerol-phosphate dehydratase.
  
  
 0.755
Tcur_4503
KEGG: afw:Anae109_2337 dihydropteroate synthase; TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase DHPS.
  
    0.592
Your Current Organism:
Thermomonospora curvata
NCBI taxonomy Id: 471852
Other names: T. curvata DSM 43183, Thermomonospora curvata DSM 43183, Thermomonospora curvata IFO 15933, Thermomonospora curvata JCM 3096, Thermomonospora curvata NBRC 15933, Thermomonospora curvata str. DSM 43183, Thermomonospora curvata strain DSM 43183
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