Tcur_1193 protein (Thermomonospora curvata) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

Tcur_1193

PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein. (411 aa)

Predicted Functional Partners:

Tcur_2767

0.750

Tcur_2082

0.610

Tcur_1192

0.589

Tcur_3225

0.555

Tcur_2500

0.544

Tcur_1677

0.537

Tcur_1090

0.503

Tcur_1998

0.474

Tcur_3160

0.462

Tcur_0305

0.452

Your Current Organism:

Thermomonospora curvata

NCBI taxonomy Id: 471852
Other names: T. curvata DSM 43183, Thermomonospora curvata DSM 43183, Thermomonospora curvata IFO 15933, Thermomonospora curvata JCM 3096, Thermomonospora curvata NBRC 15933, Thermomonospora curvata str. DSM 43183, Thermomonospora curvata strain DSM 43183

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Tcur_0305	Tcur_1193	KEGG: hypothetical protein.	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	0.452
Tcur_1090	Tcur_1193	KEGG: Os05g0227600; hypothetical protein.	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	0.503
Tcur_1090	Tcur_2082	KEGG: Os05g0227600; hypothetical protein.	KEGG: hypothetical protein.	0.485
Tcur_1090	Tcur_2500	KEGG: Os05g0227600; hypothetical protein.	KEGG: hypothetical protein.	0.429
Tcur_1090	Tcur_3160	KEGG: Os05g0227600; hypothetical protein.	Hypothetical protein.	0.432
Tcur_1192	Tcur_1193	Citrate (pro-3S)-lyase; PFAM: HpcH/HpaI aldolase; KEGG: rhi:NGR_c26230 putative citrate lyase; Belongs to the HpcH/HpaI aldolase family.	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	0.589
Tcur_1193	Tcur_0305	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	KEGG: hypothetical protein.	0.452
Tcur_1193	Tcur_1090	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	KEGG: Os05g0227600; hypothetical protein.	0.503
Tcur_1193	Tcur_1192	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	Citrate (pro-3S)-lyase; PFAM: HpcH/HpaI aldolase; KEGG: rhi:NGR_c26230 putative citrate lyase; Belongs to the HpcH/HpaI aldolase family.	0.589
Tcur_1193	Tcur_1677	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	Hypothetical protein.	0.537
Tcur_1193	Tcur_1998	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; Tetratricopeptide TPR_4; SMART: regulatory protein LuxR; KEGG: rlt:Rleg2_5436 transcriptional regulator, LuxR family.	0.474
Tcur_1193	Tcur_2082	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	KEGG: hypothetical protein.	0.610
Tcur_1193	Tcur_2500	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	KEGG: hypothetical protein.	0.544
Tcur_1193	Tcur_2767	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	PFAM: protein of unknown function DUF181; MoeZ/MoeB domain protein; KEGG: scl:sce0227 hypothetical protein.	0.750
Tcur_1193	Tcur_3160	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	Hypothetical protein.	0.462
Tcur_1193	Tcur_3225	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	PFAM: Antibiotic biosynthesis monooxygenase.	0.555
Tcur_1677	Tcur_1193	Hypothetical protein.	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	0.537
Tcur_1677	Tcur_2082	Hypothetical protein.	KEGG: hypothetical protein.	0.402
Tcur_1998	Tcur_1193	Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; Tetratricopeptide TPR_4; SMART: regulatory protein LuxR; KEGG: rlt:Rleg2_5436 transcriptional regulator, LuxR family.	PFAM: Abortive infection protein; KEGG: ccs:CCNA_00229 CAAX amino terminal protease family protein.	0.474
Tcur_2082	Tcur_1090	KEGG: hypothetical protein.	KEGG: Os05g0227600; hypothetical protein.	0.485

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Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.708

expected number of edges:

13

PPI enrichment p-value:

1.09e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015288

Porin activity

4 of 19

2.0

2.05

6.74e-05

GO:0022857

Transmembrane transporter activity

5 of 322

0.87

0.47

0.0456

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019867

Outer membrane

3 of 60

1.38

0.67

0.0365

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7125

Mixed, incl. Clostripain family, and Integrin alpha (beta-propellor repeats).

5 of 12

2.3

3.92

1.17e-08

CL:7117

Mixed, incl. Outer membrane, and Quorum sensing

9 of 112

1.58

3.03

7.80e-11

CL:7128

Clostripain family, and Integrin alpha (beta-propellor repeats).

3 of 6

2.38

2.32

3.93e-05

CL:7248

TonB box, and OmpA family

4 of 23

1.92

2.27

1.40e-05

CL:7249

TonB box, and WD40-like Beta Propeller Repeat

3 of 18

1.9

1.61

0.00052

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02040

Flagellar assembly

3 of 49

1.47

0.81

0.0184

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0046930

Pore complex

3 of 8

2.25

1.83

0.00033

GOCC:0005576

Extracellular region

4 of 138

1.14

0.67

0.0218

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0732

Signal

8 of 384

1.0

1.02

2.54e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03415

Clostripain family

3 of 3

2.68

2.18

9.68e-05

PF00691

OmpA family

3 of 8

2.25

1.79

0.00040

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00060

Fibronectin type 3 domain

3 of 12

2.08

1.73

0.00041

SM00327

Von Willebrand factor (vWF) type A domain

3 of 17

1.93

1.63

0.00051

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