STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tcur_2011PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; NAD-dependent epimerase/dehydratase; KEGG: short chain dehydrogenase/reductase family. (255 aa)    
Predicted Functional Partners:
Tcur_2712
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: pau:PA14_19730 oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
     0.730
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.687
Tcur_0268
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bac:BamMC406_3907 short-chain dehydrogenase/reductase SDR.
 
 
 0.656
Tcur_3953
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: abc:ACICU_01831 dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
    0.651
Tcur_2692
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: aci:ACIAD3298 putative short-chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 
 0.595
Tcur_3770
PFAM: short-chain dehydrogenase/reductase SDR; NAD- dependent epimerase/dehydratase; KEGG: rfr:Rfer_0320 short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 
 
 0.554
Tcur_2012
PFAM: Ppx/GppA phosphatase; KEGG: gsu:GSU2559 exopolyphosphatase, putative.
     
 0.528
Tcur_2010
PFAM: major facilitator superfamily MFS_1; KEGG: pol:Bpro_1369 major facilitator superfamily MFS_1.
   
 0.498
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
    
 0.483
Tcur_0107
PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein TPP binding domain protein; KEGG: dia:Dtpsy_2811 thiamine pyrophosphate protein domain protein TPP-binding.
 
 0.457
Your Current Organism:
Thermomonospora curvata
NCBI taxonomy Id: 471852
Other names: T. curvata DSM 43183, Thermomonospora curvata DSM 43183, Thermomonospora curvata IFO 15933, Thermomonospora curvata JCM 3096, Thermomonospora curvata NBRC 15933, Thermomonospora curvata str. DSM 43183, Thermomonospora curvata strain DSM 43183
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