STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tcur_3565PFAM: Methionine synthase vitamin-B12 independent; KEGG: dal:Dalk_5194 hypothetical protein. (337 aa)    
Predicted Functional Partners:
Tcur_2292
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
  
 0.860
Tcur_3026
KEGG: ank:AnaeK_2769 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.853
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.819
Tcur_3566
PFAM: Luciferase-like monooxygenase; KEGG: rpb:RPB_4411 luciferase-like.
       0.762
mnmA
tRNA(5-methylaminomethyl-2-thiouridylate)-methyl transferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
       0.737
Tcur_3368
PFAM: GCN5-related N-acetyltransferase; KEGG: mxa:MXAN_1267 hypothetical protein.
  
     0.729
Tcur_1647
KEGG: ccs:CCNA_02657 hypothetical protein.
  
     0.727
Tcur_3151
PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mca:MCA1018 ErfK/YbiS/YcfS/YnhG family protein.
  
     0.713
Tcur_2614
PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mca:MCA1018 ErfK/YbiS/YcfS/YnhG family protein.
  
     0.705
Tcur_3075
PFAM: ErfK/YbiS/YcfS/YnhG family protein; KEGG: mca:MCA1018 ErfK/YbiS/YcfS/YnhG family protein.
  
     0.702
Your Current Organism:
Thermomonospora curvata
NCBI taxonomy Id: 471852
Other names: T. curvata DSM 43183, Thermomonospora curvata DSM 43183, Thermomonospora curvata IFO 15933, Thermomonospora curvata JCM 3096, Thermomonospora curvata NBRC 15933, Thermomonospora curvata str. DSM 43183, Thermomonospora curvata strain DSM 43183
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