STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Bcav_2796Uroporphyrinogen III synthase HEM4; PFAM: Transcriptional regulatory protein, C terminal; Uroporphyrinogen-III synthase HemD. (381 aa)    
Predicted Functional Partners:
Bcav_2797
uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: siroheme synthase, N-terminal domain; uroporphyrin-III C-methyltransferase.
 
 
 0.997
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.984
Bcav_2799
Nitrite reductase (NAD(P)H), large subunit; PFAM: Pyridine nucleotide-disulphide oxidoreductase; BFD-like [2Fe-2S] binding domain; Nitrite/Sulfite reductase ferredoxin-like half domain; Nitrite and sulphite reductase 4Fe-4S domain; TIGRFAM: nitrite reductase [NAD(P)H], large subunit.
 
  
 0.962
Bcav_2798
PFAM: Rieske [2Fe-2S] domain; TIGRFAM: nitrite reductase [NAD(P)H], small subunit.
 
  
 0.952
Bcav_4010
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.945
Bcav_2795
Cobalamin (vitamin B12) biosynthesis CbiX protein; PFAM: CbiX.
 
  
 0.934
Bcav_4013
Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
     
 0.901
Bcav_2802
PFAM: Major Facilitator Superfamily; TIGRFAM: nitrite extrusion protein (nitrite facilitator).
 
  
 0.886
Bcav_2801
PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
 
   
 0.878
Bcav_2800
PFAM: BFD-like [2Fe-2S] binding domain; Pyridine nucleotide-disulphide oxidoreductase.
 
  
 0.847
Your Current Organism:
Beutenbergia cavernae
NCBI taxonomy Id: 471853
Other names: B. cavernae DSM 12333, Beutenbergia cavernae DSM 12333, Beutenbergia cavernae str. DSM 12333, Beutenbergia cavernae strain DSM 12333
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